Beyond Uniform Impairment: Investigating Declarative Memory Profiles in Nonspecific Mild Intellectual Disability Using Latent Profile Analysis.

IF 2 2区 医学 Q1 EDUCATION, SPECIAL
Urszula Sajewicz-Radtke, Bartosz M Radtke, Paweł Jurek, Michał Olech, Ariadna Łada-Maśko
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引用次数: 0

Abstract

Background: Significant memory impairments are consistently observed in individuals with intellectual disabilities (ID), but considerable variability exists. This study investigated the heterogeneity of declarative memory in children and adolescents with nonspecific mild intellectual disability (NSID) to identify distinct memory profiles and potential predictors of this disability.

Methods: A latent profile analysis (LPA) was conducted on a large sample (N = 999, including 114 with NSID) using six supplementary memory indices from the Test of Memory and Learning-Second Edition (TOMAL-2). A logistic regression analysis subsequently examined the predictive power of TOMAL-2 indices for NSID diagnosis.

Results: LPA revealed two distinct memory profiles: a 'memory impaired group' (24% of the total sample) with below-average scores across all indices and a 'high-performers group' (76%) with consistently above-average scores. Individuals with NSID were significantly more likely to belong to the 'memory impaired group'. Logistic regression analysis revealed that lower scores on the Attention/Concentration Index, Sequential Memory Index and Verbal Delayed Recall Index were the strongest predictors of NSID. However, notably, 25% of individuals with mild NSID were classified in the 'high performers group', exhibiting typical or above-average memory scores across multiple indices.

Conclusions: This study demonstrates significant heterogeneity in declarative memory among individuals with NSID, challenging the assumption of uniform impairment. The identified memory profiles and predictive indices offer valuable insights for more precise diagnostic assessment and the development of tailored interventions. Further research should investigate the factors contributing to this variability and explore the potential of these findings for improved support and educational strategies.

Trial registration: NCT06215092.

超越统一的损害:使用潜在特征分析调查非特异性轻度智力残疾的陈述性记忆特征。
背景:在智力残疾(ID)的个体中一直观察到显著的记忆障碍,但存在相当大的差异。本研究调查了非特异性轻度智力残疾(NSID)儿童和青少年陈述性记忆的异质性,以确定不同的记忆特征和这种残疾的潜在预测因素。方法:采用《记忆与学习测验第二版》(TOMAL-2)中的6项补充记忆指标,对大样本(N = 999,其中NSID患者114例)进行潜在特征分析(LPA)。logistic回归分析随后检验了TOMAL-2指标对NSID诊断的预测能力。结果:LPA揭示了两种截然不同的记忆特征:“记忆受损组”(占总样本的24%)在所有指标上的得分都低于平均水平,而“表现优异组”(76%)的得分一直高于平均水平。NSID患者明显更有可能属于“记忆受损组”。Logistic回归分析显示,注意/集中指数、顺序记忆指数和言语延迟回忆指数得分较低是NSID的最强预测因子。然而,值得注意的是,25%的轻度NSID患者被归类为“高绩效组”,在多个指数中表现出典型或高于平均水平的记忆得分。结论:本研究证明了NSID患者陈述性记忆的显著异质性,挑战了统一损害的假设。确定的记忆概况和预测指数为更精确的诊断评估和量身定制的干预措施的发展提供了有价值的见解。进一步的研究应调查造成这种差异的因素,并探讨这些发现在改善支助和教育战略方面的潜力。试验注册:NCT06215092。
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来源期刊
CiteScore
5.60
自引率
5.60%
发文量
81
期刊介绍: The Journal of Intellectual Disability Research is devoted exclusively to the scientific study of intellectual disability and publishes papers reporting original observations in this field. The subject matter is broad and includes, but is not restricted to, findings from biological, educational, genetic, medical, psychiatric, psychological and sociological studies, and ethical, philosophical, and legal contributions that increase knowledge on the treatment and prevention of intellectual disability and of associated impairments and disabilities, and/or inform public policy and practice. Expert reviews on themes in which recent research has produced notable advances will be included. Such reviews will normally be by invitation.
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