{"title":"Adolescent Sleep Disruption: Implications for Psychiatric Morbidity.","authors":"Leila Tarokh, Carolina Guiterrez Herrera","doi":"10.1016/j.biopsych.2025.08.010","DOIUrl":null,"url":null,"abstract":"<p><p>Adolescence marks a critical developmental period characterized by rapid brain maturation and heightened vulnerability to psychiatric disorders. This review underscores the pivotal role of sleep in adolescent development and its bidirectional relationship with mental health. We identify how genetic and long- and short-term environmental factors link sleep disturbance to psychiatric vulnerability. The review emphasizes the potential of transdiagnostic frameworks that consider sleep abnormalities as core features across various psychiatric conditions. Interventions targeting sleep, both behavioral and pharmacological, have shown promise in improving mental health outcomes and vice versa. We advocate for integrated, developmentally informed approaches to treating psychiatric disorders, considering sleep as both a diagnostic marker and a therapeutic target. By reframing adolescent sleep disruption as a key factor in psychiatric morbidity, we call for multidisciplinary research to disentangle causal pathways and promote resilience through early sleep-focused interventions.</p>","PeriodicalId":8918,"journal":{"name":"Biological Psychiatry","volume":" ","pages":""},"PeriodicalIF":9.0000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.biopsych.2025.08.010","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Adolescence marks a critical developmental period characterized by rapid brain maturation and heightened vulnerability to psychiatric disorders. This review underscores the pivotal role of sleep in adolescent development and its bidirectional relationship with mental health. We identify how genetic and long- and short-term environmental factors link sleep disturbance to psychiatric vulnerability. The review emphasizes the potential of transdiagnostic frameworks that consider sleep abnormalities as core features across various psychiatric conditions. Interventions targeting sleep, both behavioral and pharmacological, have shown promise in improving mental health outcomes and vice versa. We advocate for integrated, developmentally informed approaches to treating psychiatric disorders, considering sleep as both a diagnostic marker and a therapeutic target. By reframing adolescent sleep disruption as a key factor in psychiatric morbidity, we call for multidisciplinary research to disentangle causal pathways and promote resilience through early sleep-focused interventions.
期刊介绍:
Biological Psychiatry is an official journal of the Society of Biological Psychiatry and was established in 1969. It is the first journal in the Biological Psychiatry family, which also includes Biological Psychiatry: Cognitive Neuroscience and Neuroimaging and Biological Psychiatry: Global Open Science. The Society's main goal is to promote excellence in scientific research and education in the fields related to the nature, causes, mechanisms, and treatments of disorders pertaining to thought, emotion, and behavior. To fulfill this mission, Biological Psychiatry publishes peer-reviewed, rapid-publication articles that present new findings from original basic, translational, and clinical mechanistic research, ultimately advancing our understanding of psychiatric disorders and their treatment. The journal also encourages the submission of reviews and commentaries on current research and topics of interest.