Oxidative stress response protein delays ovarian aging by promoting stress granule clearance

Abstract

Analysis of granulosa cells from participants with age-related or pathological ovarian aging identified a crucial factor — NCOA7 — that promotes stress granule clearance via autophagy (‘granulophagy’), conferring protection against ovarian aging. Boosting NCOA7 activity or granulophagy alleviates senescence in granulosa cells and delays ovarian aging, suggesting new therapeutic strategies.