Implications of Value Set Choice on EQ-5D-Y-3L Child and Proxy Health-Related Quality of Life Ratings: What to Do When a Country-Specific "Y" Value Set Is Unavailable?

IF 6 2区医学 Q1 ECONOMICS

Value in Health Pub Date : 2025-08-19 DOI:10.1016/j.jval.2025.08.004

Diana Khanna, Jyoti Khadka, Christine Mpundu-Kaambwa, Rachel Milte, Julie Ratcliffe

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引用次数: 0

Abstract

Objectives: There is limited guidance on whether to apply an available EQ-5D-Y-3L "Y" value set from another country or use a country-specific EQ-5D-3L "adult" value set when a country-specific "Y" value set is unavailable. This study aims to examine how the choice of value set (ie, "Y" or "adult") influences the interrater gap between child-self and proxy-reported health-related quality of life (HRQoL).

Methods: An online sample of 845 dyads (children aged 6-10 years and parents) independently completed the self and proxy versions of the EQ-5D-Y-3L. Corresponding HRQoL values were derived using the "Y" and the "adult" value sets for 5 countries: Germany, Hungary, Japan, The Netherlands, and Spain. Analyses were stratified by age (6-7 vs 8-10-year-olds), gender (boys vs girls), and health condition (no vs yes). Group differences were identified using paired t tests. The percentage of directional consistency in child-proxy discrepancies across value sets was also examined as a secondary analysis.

Results: Proxies significantly overestimated HRQoL values across most "Y" value sets (Hungary, Japan, and Spain). Significant discrepancies using the corresponding "adult" value sets were observed only for Germany. Additionally, significant interrater differences were observed for children without health conditions across all value sets. Proportional agreement in direction was marginally higher when using "Y" value sets, except for Germany.

Conclusions: The choice of value set influences child-proxy HRQoL assessments. In the absence of a country-specific "Y" value set, using an alternative "Y" value set is preferable to relying solely on a country-specific "adult" value set.

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值集选择对EQ-5D-Y-3L儿童和代理HRQoL评分的影响：当国家特定的“Y”值集不可用时该怎么办？

目的：对于是否应用来自其他国家的可用EQ-5D-Y-3L“Y”值集，或者在无法获得特定国家的“Y”值集时使用特定国家的EQ-5D-3L“成人”值集，目前的指导有限。本研究旨在检验值集（即“Y”或“成人”）的选择如何影响儿童自我和代理报告的健康相关生活质量（HRQoL）之间的评分差距。方法：在线抽样845对（6-10岁儿童和家长）独立完成EQ-5D-Y-3L的自我版和代理版。相应的HRQoL值是使用“Y”和“成人”值集得出的，这五个国家是：德国、匈牙利、日本、荷兰和西班牙。分析按年龄（6-7岁vs 8-10岁）、性别和健康状况分层。使用配对t检验确定组间差异。跨值集的儿童代理差异的方向一致性百分比也作为次要分析进行了检查。结果：代理在大多数“Y”值集（匈牙利、日本、西班牙）中显著高估了HRQoL值。使用相应的“成人”值集，仅在德国观察到显著差异。此外，在所有值集中，对没有健康状况的儿童观察到显著的评分间差异。当使用“Y”值集时，除德国外，方向上的比例一致性略高。结论：值集的选择影响儿童代理HRQoL的评价。在没有特定国家的“Y”值集的情况下，使用替代的“Y”值集比完全依赖特定国家的“成人”值集更可取。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Value in Health 医学-卫生保健

CiteScore

6.90

自引率

6.70%

发文量

3064

审稿时长

3-8 weeks

期刊介绍： Value in Health contains original research articles for pharmacoeconomics, health economics, and outcomes research (clinical, economic, and patient-reported outcomes/preference-based research), as well as conceptual and health policy articles that provide valuable information for health care decision-makers as well as the research community. As the official journal of ISPOR, Value in Health provides a forum for researchers, as well as health care decision-makers to translate outcomes research into health care decisions.