Myles R McCrary, Riechelle Garcia, Janice Jiang, Michael B Morgan
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引用次数: 0
Abstract
Cutaneous large cell neuroendocrine carcinoma (LCNEC) is a rare and poorly understood malignancy. Here we describe the clinicopathological characteristics of six cutaneous LCNEC case. A retrospective chart and slide review of PCLCNEC cases at a large commercial dermatopathology practice from January 2017 to May 2025 was performed. Patient characteristics, histopathologic features, and immunohistochemical profiles, including Merkel cell polyoma virus large T antigen/MCPyV antigenicity, were summarized. Demographically, PCLCNEC occurred in elderly white patients, presenting as a rapidly progressing nodule in sun-exposed skin. Histologically, the tumors were characterized by predominantly infiltrative growth patterns with varying levels of neuroendocrine architectural and cytologic features, including rosette and trabeculae formation, organoid nesting, and peripheral palisading. All were positive for CK7 and neuroendocrine markers and negative for MCPyV, CK20, and TTF1 expression by immunohistochemistry. Metastasis was identified in one patient, while the remaining five patients had no evidence of disease following wide local excision with a median follow-up period of 25 months. This series contributes valuable insights into the characterization and diagnosis of primary cutaneous LCNEC. In conjunction with previously reported data, we suggest that the morphology and immunophenotype support further inquiry into its potential distinction as a unique cutaneous entity.
期刊介绍:
Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.