Histopathologic and Immunophenotypic Properties of Primary Cutaneous Large Cell Neuroendocrine Carcinomas.

IF 1.1 4区 医学 Q3 DERMATOLOGY
Myles R McCrary, Riechelle Garcia, Janice Jiang, Michael B Morgan
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引用次数: 0

Abstract

Cutaneous large cell neuroendocrine carcinoma (LCNEC) is a rare and poorly understood malignancy. Here we describe the clinicopathological characteristics of six cutaneous LCNEC case. A retrospective chart and slide review of PCLCNEC cases at a large commercial dermatopathology practice from January 2017 to May 2025 was performed. Patient characteristics, histopathologic features, and immunohistochemical profiles, including Merkel cell polyoma virus large T antigen/MCPyV antigenicity, were summarized. Demographically, PCLCNEC occurred in elderly white patients, presenting as a rapidly progressing nodule in sun-exposed skin. Histologically, the tumors were characterized by predominantly infiltrative growth patterns with varying levels of neuroendocrine architectural and cytologic features, including rosette and trabeculae formation, organoid nesting, and peripheral palisading. All were positive for CK7 and neuroendocrine markers and negative for MCPyV, CK20, and TTF1 expression by immunohistochemistry. Metastasis was identified in one patient, while the remaining five patients had no evidence of disease following wide local excision with a median follow-up period of 25 months. This series contributes valuable insights into the characterization and diagnosis of primary cutaneous LCNEC. In conjunction with previously reported data, we suggest that the morphology and immunophenotype support further inquiry into its potential distinction as a unique cutaneous entity.

原发性皮肤大细胞神经内分泌癌的组织病理学和免疫表型特征。
摘要皮肤大细胞神经内分泌癌(LCNEC)是一种罕见且了解甚少的恶性肿瘤。本文报告6例皮肤LCNEC病例的临床病理特点。对2017年1月至2025年5月一家大型商业皮肤病理学诊所的PCLCNEC病例进行回顾性图表和幻灯片回顾。总结了患者特征、组织病理学特征和免疫组织化学特征,包括默克尔细胞多瘤病毒大T抗原/MCPyV抗原性。人口统计学上,PCLCNEC发生在老年白人患者中,表现为暴露在阳光下的皮肤上快速发展的结节。组织学上,肿瘤主要表现为浸润性生长模式,具有不同程度的神经内分泌建筑和细胞学特征,包括玫瑰花结和小梁形成、类器官巢和周围栅栏。所有患者的CK7和神经内分泌标志物均呈阳性,MCPyV、CK20和TTF1免疫组化表达均呈阴性。1例患者发现转移,而其余5例患者在广泛局部切除后无疾病证据,中位随访期为25个月。这一系列为原发性皮肤LCNEC的特征和诊断提供了有价值的见解。结合先前报道的数据,我们建议形态学和免疫表型支持进一步调查其作为独特皮肤实体的潜在区别。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
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