Association of dietary index for gut microbiota and sarcopenia: the mediation effect of body roundness index.

IF 4.3 3区医学 Q1 GERIATRICS & GERONTOLOGY

Innovation in Aging Pub Date : 2025-06-20 eCollection Date: 2025-07-01 DOI:10.1093/geroni/igaf065

Shan Li, Huanhuan Huang, Haoning Shi, Zhiyu Chen, Siqi Jiang, Xinyu Yu, Keke Ren, Qi Huang, Qinghua Zhao

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Abstract

Background and objectives: The complex interplay between diet, gut microbiota, and metabolic health has gained increasing recognition as a key factor in the development of obesity and related conditions, such as sarcopenia. This study examines the relationship between the dietary index for gut microbiota (DI-GM) and sarcopenia, while exploring the potential mediating role of the body roundness index (BRI) in this association. By integrating these factors, our findings aim to shed light on the diet-gut microbiota-sarcopenia interaction and its implications for personalized dietary interventions.

Research design and methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. Multivariable weighted regression analyses were conducted to assess the association between DI-GM and sarcopenia. Restricted cubic spline analyses were used to evaluate potential non-linear relationships. Additionally, mediation analysis was performed to determine whether the BRI mediated the relationship between DI-GM and sarcopenia.

Results: A total of 10,190 participants were included in the study, of whom 7.57% were diagnosed with sarcopenia. In the weighted linear regression analysis, each one-point increase in DI-GM was associated with a 12% reduction in the prevalence of sarcopenia (OR = 0.88, 95% CI: 0.82, 0.95). Specifically, a higher beneficial gut microbiota score was significantly associated with a lower prevalence of sarcopenia (OR = 0.82, 95% CI: 0.75, 0.89). Mediation analysis revealed that BRI accounted for 23% of the total effect of DI-GM on sarcopenia. Among the beneficial components, those with a significant mediation effect contributed approximately 9% of the total effect.

Discussion and implications: The DI-GM was found to be negatively associated with the prevalence of sarcopenia, with BRI playing a crucial mediating role. These findings highlight the importance of the diet-gut microbiota-sarcopenia interaction and underscore the potential for incorporating dietary and microbiota-targeted interventions in personalized therapeutic strategies for sarcopenia.

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肠道菌群膳食指数与肌肉减少症的关系：体圆指数的中介作用。

背景和目的：饮食、肠道微生物群和代谢健康之间复杂的相互作用已经越来越多地被认为是肥胖和相关疾病（如肌肉减少症）发展的关键因素。本研究探讨了肠道微生物群膳食指数（DI-GM）与肌肉减少症之间的关系，同时探讨了身体圆度指数（BRI）在这一关联中的潜在中介作用。通过整合这些因素，我们的研究结果旨在阐明饮食-肠道微生物群-肌肉减少症的相互作用及其对个性化饮食干预的影响。研究设计与方法：数据来源于2011-2018年国家健康与营养检查调查（NHANES）。采用多变量加权回归分析来评估DI-GM与肌肉减少症之间的关系。限制三次样条分析用于评估潜在的非线性关系。此外，还进行了中介分析，以确定BRI是否介导了DI-GM与肌肉减少症之间的关系。结果：共有10,190名参与者纳入研究，其中7.57%被诊断为肌肉减少症。在加权线性回归分析中，DI-GM每增加1点与肌肉减少症患病率降低12%相关（OR = 0.88, 95% CI: 0.82, 0.95）。具体而言，较高的有益肠道菌群评分与较低的肌肉减少症患病率显著相关（OR = 0.82, 95% CI: 0.75, 0.89）。中介分析显示BRI占DI-GM对肌肉减少症总效应的23%。在有益成分中，具有显著中介效应的成分约占总效应的9%。讨论和意义：发现DI-GM与肌肉减少症的患病率呈负相关，BRI在其中起着关键的中介作用。这些发现强调了饮食-肠道微生物群-肌肉减少症相互作用的重要性，并强调了将饮食和微生物群靶向干预纳入肌肉减少症个性化治疗策略的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Innovation in Aging GERIATRICS & GERONTOLOGY-

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Innovation in Aging, an interdisciplinary Open Access journal of the Gerontological Society of America (GSA), is dedicated to publishing innovative, conceptually robust, and methodologically rigorous research focused on aging and the life course. The journal aims to present studies with the potential to significantly enhance the health, functionality, and overall well-being of older adults by translating scientific insights into practical applications. Research published in the journal spans a variety of settings, including community, clinical, and laboratory contexts, with a clear emphasis on issues that are directly pertinent to aging and the dynamics of life over time. The content of the journal mirrors the diverse research interests of GSA members and encompasses a range of study types. These include the validation of new conceptual or theoretical models, assessments of factors impacting the health and well-being of older adults, evaluations of interventions and policies, the implementation of groundbreaking research methodologies, interdisciplinary research that adapts concepts and methods from other fields to aging studies, and the use of modeling and simulations to understand factors and processes influencing aging outcomes. The journal welcomes contributions from scholars across various disciplines, such as technology, engineering, architecture, economics, business, law, political science, public policy, education, public health, social and psychological sciences, biomedical and health sciences, and the humanities and arts, reflecting a holistic approach to advancing knowledge in gerontology.