Investigation of the Effect of Krill Oil on Sortilin in Liver and Adipose Tissue in Obese Rats

IF 4.2 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Molecular Nutrition & Food Research Pub Date : 2025-08-30 DOI:10.1002/mnfr.70233

Mehtap Atak, Ayse Beyza Sahin, Eda Yilmaz Kutlu, Hulya Kilic, Huseyin Avni Uydu, Hatice Sevim Nalkiran, Ertugrul Yigit

{"title":"Investigation of the Effect of Krill Oil on Sortilin in Liver and Adipose Tissue in Obese Rats","authors":"Mehtap Atak, Ayse Beyza Sahin, Eda Yilmaz Kutlu, Hulya Kilic, Huseyin Avni Uydu, Hatice Sevim Nalkiran, Ertugrul Yigit","doi":"10.1002/mnfr.70233","DOIUrl":null,"url":null,"abstract":"Sortilin regulates lipid metabolism, adipogenesis, and inflammation in obesity. While the anti‐inflammatory and lipid‐modulating effects of krill oil (KO) on obesity are well known, its effects on sortilin remain insufficiently investigated. This study investigates the potential effects of KO supplementation on sortilin and pro‐inflammatory cytokine levels in rats fed a high‐fat diet (HFD).Twenty‐four male Sprague Dawley rats were randomly assigned to three groups: standard diet (SD), HFD, and HFD + KO (600 mg/kg/day KO via oral gavage for 12 weeks). Body weights were monitored weekly. Serum total cholesterol (TC), triglyceride, glucose, insulin, and HOMA‐IR were measured. Sortilin, TNF‐α, IL‐1β, and IL‐6 levels were assessed in liver and retroperitoneal (RP) adipose tissues. The HFD group showed significant increases in weight, TC, glucose, and HOMA‐IR, with decreased hepatic and increased RP adipose sortilin and TNF‐α levels. KO reduced serum TC, increased hepatic sortilin and TNF‐α, and decreased their levels in RP adipose tissue. These findings indicate that KO exerts a protective effect against HFD‐induced obesity and inflammation by modulating lipid metabolism, reducing TNF‐α and sortilin levels. Therefore, KO may serve as a promising dietary intervention for mitigating obesity‐related metabolic and inflammatory complications.","PeriodicalId":212,"journal":{"name":"Molecular Nutrition & Food Research","volume":"26 1","pages":""},"PeriodicalIF":4.2000,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Nutrition & Food Research","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1002/mnfr.70233","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Sortilin regulates lipid metabolism, adipogenesis, and inflammation in obesity. While the anti‐inflammatory and lipid‐modulating effects of krill oil (KO) on obesity are well known, its effects on sortilin remain insufficiently investigated. This study investigates the potential effects of KO supplementation on sortilin and pro‐inflammatory cytokine levels in rats fed a high‐fat diet (HFD).Twenty‐four male Sprague Dawley rats were randomly assigned to three groups: standard diet (SD), HFD, and HFD + KO (600 mg/kg/day KO via oral gavage for 12 weeks). Body weights were monitored weekly. Serum total cholesterol (TC), triglyceride, glucose, insulin, and HOMA‐IR were measured. Sortilin, TNF‐α, IL‐1β, and IL‐6 levels were assessed in liver and retroperitoneal (RP) adipose tissues. The HFD group showed significant increases in weight, TC, glucose, and HOMA‐IR, with decreased hepatic and increased RP adipose sortilin and TNF‐α levels. KO reduced serum TC, increased hepatic sortilin and TNF‐α, and decreased their levels in RP adipose tissue. These findings indicate that KO exerts a protective effect against HFD‐induced obesity and inflammation by modulating lipid metabolism, reducing TNF‐α and sortilin levels. Therefore, KO may serve as a promising dietary intervention for mitigating obesity‐related metabolic and inflammatory complications.

查看原文本刊更多论文

磷虾油对肥胖大鼠肝脏及脂肪组织Sortilin影响的研究

Sortilin调节肥胖的脂质代谢、脂肪形成和炎症。虽然众所周知磷虾油（KO）对肥胖的抗炎和脂质调节作用，但其对sortilin的影响仍未得到充分研究。本研究探讨了KO补充剂对高脂饮食（HFD）大鼠sortilin和促炎细胞因子水平的潜在影响。24只雄性Sprague Dawley大鼠随机分为三组：标准饮食（SD）、HFD和HFD + KO （600 mg/kg/天灌胃KO，持续12周）。每周监测体重。测定血清总胆固醇（TC）、甘油三酯、葡萄糖、胰岛素和HOMA‐IR。评估肝脏和腹膜后（RP）脂肪组织中Sortilin、TNF‐α、IL‐1β和IL‐6的水平。HFD组显示体重、TC、葡萄糖和HOMA‐IR显著增加，肝脏脂肪sortilin和TNF‐α水平降低，RP脂肪sortilin和TNF‐α水平升高。KO降低了血清TC，增加了肝脏sortilin和TNF - α，并降低了RP脂肪组织中它们的水平。这些发现表明，KO通过调节脂质代谢、降低TNF - α和sortilin水平，对HFD诱导的肥胖和炎症具有保护作用。因此，KO可能作为一种有希望的饮食干预来减轻肥胖相关的代谢和炎症并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.