Supramolecular self-assembly for probiotic delivery in food system: responsive strategies, multifunctional carriers, future perspectives

IF 15.4 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Trends in Food Science & Technology Pub Date : 2025-08-28 DOI:10.1016/j.tifs.2025.105266

Li Song , Haoting Xu , Chaofan Chen , Yubin Zhang , Zihao Zhang , Xiangfeng Chen , Shunxun Liu , Hang Xiao , Qing Gu , Ping Li

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引用次数: 0

Abstract

Background

Probiotics are widely utilized in functional foods to enhance gut health, modulate immunity, and maintain metabolic balance. However, their efficacy is often limited by processing, storage, and gastrointestinal (GI) challenges. Traditional encapsulation provides limited protection, further highlighting the need for intelligent, food-compatible delivery systems. Supramolecular self-assembly, based on reversible non-covalent interactions, provides a promising strategy for constructing dynamic and responsive probiotic delivery systems tailored to food applications.

Scope and approach

This review focuses on recent advances in supramolecular self-assembly for intelligent probiotic delivery. It discusses: (1) the non-covalent interactions driving supramolecular self-assembly architectures; (2) the innovative applications in probiotic carrier systems such as microcapsules, hydrogels, nanocoatings, liposome and exosome coatings; (3) emerging co-delivery strategies with prebiotics, antioxidants and next-generation probiotics (NGPs), as well as the application in food and health regulation.

Key findings and conclusions

Supramolecular self-assembly technology enables dynamic, multilayer protection and site-specific delivery of probiotics, significantly enhancing probiotic viability and functional benefits. These systems can simultaneously encapsulate bioactive substances and NGPs to promote the development of personalized nutrition through the microbiota-metabolic axis mechanism. Moreover, they have been successfully applied in dairy, non-dairy, processed and high-moisture products. Collectively, supramolecular self-assembly technology can offer a versatile platform for future probiotic applications in functional foods and personalized nutrition.

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食物系统中益生菌传递的超分子自组装：响应策略，多功能载体，未来展望

益生菌被广泛应用于功能性食品中，以增强肠道健康，调节免疫，维持代谢平衡。然而，它们的功效往往受到加工、储存和胃肠道（GI）挑战的限制。传统的封装提供了有限的保护，进一步强调了对智能，食品兼容的输送系统的需求。基于可逆非共价相互作用的超分子自组装为构建适合食品应用的动态和响应性益生菌递送系统提供了一种有前途的策略。本文综述了近年来用于益生菌智能递送的超分子自组装技术的研究进展。讨论了：(1)驱动超分子自组装结构的非共价相互作用；(2)微胶囊、水凝胶、纳米涂层、脂质体和外泌体涂层等益生菌载体系统的创新应用；(3)与益生元、抗氧化剂和下一代益生菌（NGPs）的协同递送策略及其在食品和健康调控中的应用。超分子自组装技术实现了益生菌的动态、多层保护和位点特异性递送，显著提高了益生菌的生存能力和功能效益。这些系统可以同时包封生物活性物质和ngp，通过微生物代谢轴机制促进个性化营养的发展。此外，它们已成功地应用于乳制品，非乳制品，加工和高水分产品。总之，超分子自组装技术可以为未来益生菌在功能食品和个性化营养中的应用提供一个多功能的平台。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Food Science & Technology 工程技术-食品科技

CiteScore

32.50

自引率

2.60%

发文量

322

审稿时长

37 days

期刊介绍： Trends in Food Science & Technology is a prestigious international journal that specializes in peer-reviewed articles covering the latest advancements in technology, food science, and human nutrition. It serves as a bridge between specialized primary journals and general trade magazines, providing readable and scientifically rigorous reviews and commentaries on current research developments and their potential applications in the food industry. Unlike traditional journals, Trends in Food Science & Technology does not publish original research papers. Instead, it focuses on critical and comprehensive reviews to offer valuable insights for professionals in the field. By bringing together cutting-edge research and industry applications, this journal plays a vital role in disseminating knowledge and facilitating advancements in the food science and technology sector.