Probiotic Lactiplantibacillus plantarum Probio87 Improves Gut Microbial Profiles in HPV‐Positive Women: A Randomized, Placebo‐Controlled and Double‐Blind Study

IF 4.2 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Molecular Nutrition & Food Research Pub Date : 2025-08-30 DOI:10.1002/mnfr.70247

Pei Xu, Mageswaran Uma Mageswary, Azka Ainun Nisaa, Sarah Binti Samsudin, Nurul Izza Binti Mohamed Rusdi, Abigail Rembui Anak Jerip, Chern‐Ein Oon, Salina Binti Sany, Cheng‐Siang Tan, Zhen‐Hua Zhu, Min‐Tze Liong

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Abstract

HPV infection is a major global health concern, and recent evidence suggests that the gut microbiota may play a critical role in HPV progression and clearance. This study aimed to evaluate the modulatory effects of the probiotic strain Lactiplantibacillus plantarum Probio87 on the gut bacterial composition of HPV‐positive women. A 12‐week randomized, placebo‐controlled trial was conducted in accordance with the Declaration of Helsinki, with ethical approval from the Medical Research and Ethics Committee, Ministry of Health Malaysia (NMRR‐21‐1819‐61300), and registration at ClinicalTrials.gov (NCT05316064). Probiotic supplementation with L. plantarum Probio87 significantly modulated the gut microbiota. Specifically, reductions were observed in the relative abundance of potentially pathogenic bacteria, including Gardnerella vaginalis (p = 0.055), Fannyhessea vaginae (p = 0.039), and Bilophila species (p = 0.008). Conversely, levels of beneficial microbes such as L. plantarum (p = 0.001), Anaerotignum lactatifermentans (p = 0.039), Blautia faecis (p = 0.061), and Roseburia hominis A2‐183 (p = 0.052) were elevated. These findings suggest that L. plantarum Probio87 promotes gut microbial balance by reducing dysbiosis‐associated bacteria and enhancing beneficial populations. This modulation may contribute to improved vaginal and overall health in women with HPV infection.

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益生菌植物乳杆菌Probio87改善HPV阳性妇女肠道微生物谱：一项随机、安慰剂对照和双盲研究

HPV感染是一个主要的全球健康问题，最近的证据表明，肠道微生物群可能在HPV的进展和清除中发挥关键作用。本研究旨在评估益生菌菌株植物乳杆菌Probio87对HPV阳性妇女肠道细菌组成的调节作用。根据赫尔辛基宣言进行了一项为期12周的随机安慰剂对照试验，获得了马来西亚卫生部医学研究和伦理委员会（NMRR‐21‐1819‐61300）的伦理批准，并在ClinicalTrials.gov注册（NCT05316064）。添加植物乳杆菌益生菌87可显著调节肠道菌群。具体来说，观察到潜在致病菌的相对丰度降低，包括阴道加德纳菌（p = 0.055），阴道粉孢菌（p = 0.039）和Bilophila物种（p = 0.008）。相反，有益微生物如植物乳杆菌（L. plantarum, p = 0.001）、厌氧发酵菌（anaerotignans, p = 0.039）、粪蓝杆菌（Blautia faecis, p = 0.061）和Roseburia humanis A2‐183 （p = 0.052）水平升高。这些发现表明，植物乳杆菌Probio87通过减少与生态失调相关的细菌和增加有益菌群来促进肠道微生物平衡。这种调节可能有助于改善阴道和整体健康的妇女HPV感染。

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.