Enhancing cognition: The power of neuroplasticity

IF 12.4 1区 医学 Q1 CELL BIOLOGY
Iqra Mukhtar, Kanwal Iftikhar
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引用次数: 0

Abstract

Cognitive enhancement and neuroplasticity are interconnected terms. Neuroplasticity is an intrinsic brain capability that enables it to adapt and learn throughout life. It involves significant reorganization of neural circuits which is evident not only during normal human development but also occurs following early injury. As aging exerts a detrimental effect on various bodily systems, the extent of neuroplasticity also declines considerably. Recent evidences emphasize that cognitive enhancement can lead to positive neuroplastic changes. Moreover, neuroplastic mechanisms can be harnessed for therapeutic purposes in clinical populations in an effective manner. This approach can also pave a way for cognitive reserve and healthy aging, facilitating the protection against age-associated cognitive impairment and development of neurodegenerative disorders. However, there is an urgent need for more rigorous scientific methods to assess the effectiveness of these interventions, which is crucial for progressing in this area. In this review we aim to illuminate the promising potential of plastic processes in the nervous system. The integrated approach, combining neuromodulatory techniques such as brain stimulation with cognitive enhancement methods, is intriguing and could offer a new avenue for enhancing cognitive functions. Overall, this paper lays the groundwork for further exploration and emphasizes the importance of developing effective interventions that leverage the brain's capacity for change. Future research must refine the methodologies used to measure outcomes, ensure generalization and practical applicability, and develop strategies for implementation in real-world settings. This will ultimately enhance our understanding of how to optimize cognitive health throughout the lifespan.
增强认知:神经可塑性的力量
认知增强和神经可塑性是相互关联的术语。神经可塑性是一种内在的大脑能力,使其能够适应和学习一生。它涉及神经回路的重大重组,这不仅在正常的人类发育过程中很明显,而且在早期损伤后也会发生。随着衰老对各种身体系统产生不利影响,神经可塑性的程度也大大下降。最近的证据强调,认知增强可以导致积极的神经可塑性变化。此外,神经可塑性机制可以有效地用于临床人群的治疗目的。这种方法还可以为认知储备和健康衰老铺平道路,促进预防与年龄相关的认知障碍和神经退行性疾病的发展。然而,迫切需要更严格的科学方法来评估这些干预措施的有效性,这对于在这一领域取得进展至关重要。在这篇综述中,我们旨在阐明可塑性过程在神经系统中的潜力。将神经调节技术(如脑刺激)与认知增强方法相结合的综合方法是有趣的,可以为增强认知功能提供新的途径。总体而言,本文为进一步探索奠定了基础,并强调了开发有效干预措施的重要性,以利用大脑的变化能力。未来的研究必须改进用于测量结果的方法,确保泛化和实际适用性,并制定在现实环境中实施的策略。这将最终增强我们对如何在整个生命周期中优化认知健康的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Ageing Research Reviews
Ageing Research Reviews 医学-老年医学
CiteScore
19.80
自引率
2.30%
发文量
216
审稿时长
55 days
期刊介绍: With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.
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