Single-nucleotide polymorphisms in CYP27B1 and VDR genes associated with treatment outcomes in hepatitis B and C: A minireview

Pharmacological Research - Reports Pub Date : 2025-08-25 DOI:10.1016/j.prerep.2025.100061

Alessandra Ramalho Correia , Victor Cavicchioli , Lara Cândida de Sousa Machado , Rahisa Scussel , Ricardo Andrez Machado-de-Ávila , Iane de Oliveira Pires Porto , Iara Barreto Neves Oliveira

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Abstract

Vitamin D, essential for immune modulation, is metabolized by enzymes encoded by the CYP27B1 gene and exerts its effects through the vitamin D receptor (VDR). Genetic variations in these genes may influence antiviral response, particularly to treatments with pegylated interferon and ribavirin. This work consists of a descriptive literature review analyzing the influence of single-nucleotide polymorphisms (SNPs) in the CYP27B1 and VDR genes on the antiviral treatment response for HBV and HCV. The results indicate that specific SNPs, such as rs4646536 and rs10877012 in the CYP27B1 gene and rs7975232/ApaI, rs1544410/BsmI, rs731236/TaqI, and rs10735810—rs2228570/FokI in the VDR gene, may be associated with variable therapeutic responses, including higher rates of sustained virological response (SVR) and reduced viral load. Given the limited efficacy of current antiviral therapies, identifying relevant SNPs in genes related to the vitamin D pathway may help select responsive patients, personalize hepatitis B and C therapy approaches, and minimize side effects.

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CYP27B1和VDR基因的单核苷酸多态性与乙型和丙型肝炎治疗结果相关：一项小型综述

维生素D是免疫调节所必需的，由CYP27B1基因编码的酶代谢，并通过维生素D受体（VDR）发挥作用。这些基因的遗传变异可能影响抗病毒反应，特别是对聚乙二醇化干扰素和利巴韦林的治疗。这项工作包括描述性文献综述，分析CYP27B1和VDR基因的单核苷酸多态性（snp）对HBV和HCV抗病毒治疗反应的影响。结果表明，CYP27B1基因中的rs4646536和rs10877012以及VDR基因中的rs7975232/ApaI、rs1544410/BsmI、rs731236/TaqI和rs10735810-rs2228570 /FokI等特异性snp可能与不同的治疗反应相关，包括更高的持续病毒学反应（SVR）率和降低的病毒载量。鉴于目前抗病毒治疗的疗效有限，确定与维生素D途径相关的基因中的相关snp可能有助于选择反应性患者，个性化乙型和丙型肝炎治疗方法，并最大限度地减少副作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pharmacological Research - Reports

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