Vesicle-guided mitochondria: A new perspective for brain mitochondrial transplantation

IF 12.4 1区 医学 Q1 CELL BIOLOGY
Antonella Girgenti , Laura Palumbo , Gokhan Burcin Kubat , Ibrahim Turkel , Pasquale Picone , Domenico Nuzzo
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引用次数: 0

Abstract

Mitochondrial activity is essential for the proper functioning of higher brain processes, and its impairment has been linked to a wide range of neurological disorders. Increasing evidence shows that under physiological and pathological conditions, mitochondria can be secreted into the extracellular environment to regulate various biological responses, including cellular bioenergetics. Today, the therapeutic modality known as “mitochondrial transplantation” has emerged as a cutting-edge and highly promising intervention for the promotion of cell and tissue regeneration. This innovative approach entails the replacement of dysfunctional mitochondria in the recipient organism with healthy, functional exogenous mitochondria, thereby aiming to restore cellular function and promote tissue repair and recovery. Several studies have demonstrated the beneficial effects of local or systemic administration of mitochondria on in vitro and in vivo models of brain diseases. We discuss the effect of mitochondrial transplantation in various brain diseases and highlight some critical issues. In this regard, we propose vesicles as a delivery system for both whole mitochondria and mitochondrial components to target cells in the central nervous system. Furthermore, the aim of this review is twofold: firstly, to emphasize the significance of brain mitochondrial transplantation, and secondly, to prompt the scientific community to consider the practical applications of brain mitochondrial transplantation. To this end, the text highlights the as yet unresolved issues and challenges that must be addressed and surmounted if this field is to progress. In conclusion, the authors express their support for the development of new potential therapies for mitochondrial diseases of the central nervous system.
囊泡引导线粒体:脑线粒体移植的新视角
线粒体活动对大脑高级过程的正常运作至关重要,其损伤与广泛的神经系统疾病有关。越来越多的证据表明,在生理和病理条件下,线粒体可以分泌到细胞外环境,调节各种生物反应,包括细胞生物能量学。今天,被称为“线粒体移植”的治疗方式已经成为一种促进细胞和组织再生的前沿和非常有前途的干预手段。这种创新的方法需要用健康的、功能性的外源线粒体替代受体有机体中功能失调的线粒体,从而旨在恢复细胞功能,促进组织修复和恢复。一些研究已经证明了局部或全身给药线粒体对体外和体内脑疾病模型的有益作用。我们讨论了线粒体移植在各种脑部疾病中的作用,并强调了一些关键问题。在这方面,我们提出囊泡作为整个线粒体和线粒体成分到中枢神经系统靶细胞的递送系统。此外,本文综述的目的是双重的:一是强调脑线粒体移植的意义,二是促使科学界考虑脑线粒体移植的实际应用。为此目的,案文强调了如果这一领域要取得进展就必须处理和克服的尚未解决的问题和挑战。总之,作者表达了他们对开发中枢神经系统线粒体疾病的新潜在疗法的支持。
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来源期刊
Ageing Research Reviews
Ageing Research Reviews 医学-老年医学
CiteScore
19.80
自引率
2.30%
发文量
216
审稿时长
55 days
期刊介绍: With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.
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