Brain on standby — how torpor made ‘tauopathy’ reversible

IF 26.7 1区医学 Q1 NEUROSCIENCES

Nature Reviews Neuroscience Pub Date : 2025-08-20 DOI:10.1038/s41583-025-00964-9

Nina M. Rzechorzek

引用次数: 0

Abstract

In this Journal Club, Nina Rzechorzek explores a 2003 article showing that, during hibernation, ground squirrels reversibly accumulate highly phosphorylated tau in the brain (a hallmark of Alzheimer’s disease) without developing neurofibrillary tangle pathology.

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大脑处于待机状态——麻木如何使“脑病”可逆

在这个期刊俱乐部中，Nina Rzechorzek探讨了2003年的一篇文章，该文章表明，在冬眠期间，地松鼠在大脑中可逆地积累高度磷酸化的tau蛋白（阿尔茨海默病的标志），而不会产生神经原纤维缠结病理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neuroscience NEUROSCIENCES-

自引率

0.60%

发文量

104

期刊介绍： Nature Reviews Neuroscience is a multidisciplinary journal that covers various fields within neuroscience, aiming to offer a comprehensive understanding of the structure and function of the central nervous system. Advances in molecular, developmental, and cognitive neuroscience, facilitated by powerful experimental techniques and theoretical approaches, have made enduring neurobiological questions more accessible. Nature Reviews Neuroscience serves as a reliable and accessible resource, addressing the breadth and depth of modern neuroscience. It acts as an authoritative and engaging reference for scientists interested in all aspects of neuroscience.