Plant-derived exosomes as bioactive compounds carriers for precision nutrition

IF 15.4 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Trends in Food Science & Technology Pub Date : 2025-08-20 DOI:10.1016/j.tifs.2025.105248

Yannan Chen , Yuanyuan Liu , Huajing Gao , Qinglin Qu , Ziyue Xu , Minghan Zhang , Dapeng Li , Mingqian Tan

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引用次数: 0

Abstract

Background

Precision nutrition aims to tailor dietary recommendations and provide personalized guidance to improve nutritional health outcomes. Targeted delivery of bioactive compounds represents an effective strategy to achieve precision nutrition. Plant-derived exosomes (PDEs) are natural nanocarriers exhibiting multiple intrinsic advantages, which include enhanced biocompatibility and structural stability. The implementation of appropriate engineering strategies can endow PDEs with enhanced loading efficiency and targeting capabilities, thereby enabling site-specific delivery of bioactive compounds to fulfill precision nutrition.

Scope and approach

This review systematically evaluates engineering strategies for loading of bioactive compounds in PDEs, encompassing self-loading, physical modification, covalent modification, and non-covalent modification. Meanwhile, the potential benefits of bioactive compounds-loaded PDEs for precision nutrition are summarized, which involve enhancing stability in the gastrointestinal tract, promoting cellular uptake, intervening specific disease, and achieving targeted delivery in organ or cell levels. Finally, challenges and future perspectives of PDEs as bioactive compounds carrier for precision nutrition are further discussed.

Key findings and conclusions

Appropriate engineering strategies can enhance the loading efficiency and targeting ability of PDEs. Furthermore, PDEs can protect bioactive compounds against harsh environment, improve the gastrointestinal tract stability, and achieve target delivery and precision nutrition intervention. Future research should prioritize convergent innovations at the biology-materials-informatics interface to advance PDE design paradigms, while translational efforts must address scalability challenges for industrial adoption in nutraceutical applications.

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植物源性外泌体作为精确营养的生物活性化合物载体

精确营养旨在定制饮食建议并提供个性化指导，以改善营养健康结果。生物活性化合物的靶向递送是实现精准营养的有效策略。植物源性外泌体（PDEs）是一种天然的纳米载体，具有生物相容性和结构稳定性等多种内在优势。实施适当的工程策略可以增强pde的装载效率和靶向能力，从而实现生物活性化合物的位点特异性递送，实现精准营养。本综述系统地评价了pde中生物活性化合物负载的工程策略，包括自负载、物理修饰、共价修饰和非共价修饰。同时，总结了生物活性化合物负载的PDEs在精确营养方面的潜在益处，包括增强胃肠道稳定性，促进细胞摄取，干预特定疾病，以及在器官或细胞水平上实现靶向递送。最后，对PDEs作为精准营养载体面临的挑战及未来发展前景进行了展望。关键发现和结论适当的工程策略可以提高pde的加载效率和瞄准能力。此外，PDEs还可以保护生物活性化合物免受恶劣环境的侵害，提高胃肠道稳定性，实现靶向递送和精准营养干预。未来的研究应优先考虑生物-材料-信息学界面的融合创新，以推进PDE设计范式，而转化工作必须解决营养保健应用中工业采用的可扩展性挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Food Science & Technology 工程技术-食品科技

CiteScore

32.50

自引率

2.60%

发文量

322

审稿时长

37 days

期刊介绍： Trends in Food Science & Technology is a prestigious international journal that specializes in peer-reviewed articles covering the latest advancements in technology, food science, and human nutrition. It serves as a bridge between specialized primary journals and general trade magazines, providing readable and scientifically rigorous reviews and commentaries on current research developments and their potential applications in the food industry. Unlike traditional journals, Trends in Food Science & Technology does not publish original research papers. Instead, it focuses on critical and comprehensive reviews to offer valuable insights for professionals in the field. By bringing together cutting-edge research and industry applications, this journal plays a vital role in disseminating knowledge and facilitating advancements in the food science and technology sector.