Enhanced vestibular-evoked balance responses in adolescents with idiopathic scoliosis.

IF 2.1 3区 医学 Q3 NEUROSCIENCES
Journal of neurophysiology Pub Date : 2025-09-01 Epub Date: 2025-08-13 DOI:10.1152/jn.00238.2025
Jean-Philippe Cyr, Roxane Crepin, Pierre Mercier, Jean-Sébastien Blouin, Martin Simoneau
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引用次数: 0

Abstract

Scoliosis is a spinal deformity characterized by lateral deviation and rotation of the vertebrae, affecting between 0.47% and 5.2% of adolescents. A proposed explanation for adolescent idiopathic scoliosis (AIS) is asymmetrical vestibular function affecting the descending control of torso muscles. To verify this hypothesis, we applied stochastic vestibular stimulation (SVS) at frequencies of up to 25 Hz, both monaurally and binaurally, to standing participants with AIS (n = 15) and to those without AIS (n = 15). We characterized potential left-right vestibulomotor asymmetry in the correlations, gain, and direction of the evoked balance responses. Contrary to our hypothesis, no asymmetry in the balance responses evoked by monaural stimuli was observed in either group. AIS participants, however, exhibited larger correlations and gains (both in the frequency and time domains, except for time-domain estimates to monaural right stimuli) between vestibular stimuli and ground reaction forces compared to control participants. This larger coupling suggests a greater association between the vestibular error and force signals in AIS participants for monaural left and binaural SVS conditions. The orientation of the vestibular-evoked balance responses, however, did not differ between groups. We conclude that adolescents with idiopathic scoliosis exhibit larger vestibular gains than control participants. This suggests an enhanced relationship between the electrical vestibular error signal and the evoked balance responses. Still, these changes do not affect the symmetry or orientation of vestibular-evoked postural responses at the tested frequencies.NEW & NOTEWORTHY We tested the hypothesis that adolescent idiopathic scoliosis (AIS) patients exhibit asymmetries in the vestibular control of balance. We observed larger vestibular-evoked balance responses in participants with AIS to stimuli targeting primary vestibular afferents unilaterally and bilaterally. These larger balance-correcting responses of vestibular origin, however, were symmetric and oriented in the expected interaural direction. Our results indicate a strengthened connection between the vestibular error signals evoked by electrical stimuli and the resulting balance responses in participants with AIS.

青少年特发性脊柱侧凸的前庭诱发平衡反应增强。
脊柱侧凸是一种脊柱畸形,其特征是椎体侧偏和旋转,青少年发病率在0.47%至5.2%之间。对青少年特发性脊柱侧凸(AIS)提出的解释是不对称前庭功能影响躯干肌肉的下行控制。为了验证这一假设,我们对站立的AIS患者(n = 15)和非AIS患者(n = 15)分别采用单耳和双耳频率高达25 Hz的随机前庭刺激(SVS)。我们在诱发平衡反应的相关性、增益和方向上表征了潜在的左右前庭运动不对称性。与我们的假设相反,在两组中均未观察到单声刺激引起的平衡反应不对称。然而,与对照组相比,AIS参与者在前庭刺激和地面反作用力之间表现出更大的相关性和增益(在频率和时间域,除了对单耳右侧刺激的时域估计)。这种更大的耦合表明,在单耳左耳和双耳SVS条件下,AIS参与者的前庭误差和力信号之间存在更大的关联。然而,前庭诱发平衡反应的方向在两组之间没有差异。我们的结论是,青少年特发性脊柱侧凸表现出比对照组更大的前庭增益。这表明前庭电信号误差与诱发平衡反应之间的关系增强。尽管如此,这些变化并不影响在测试频率下前庭诱发的姿势反应的对称性或方向性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of neurophysiology
Journal of neurophysiology 医学-神经科学
CiteScore
4.80
自引率
8.00%
发文量
255
审稿时长
2-3 weeks
期刊介绍: The Journal of Neurophysiology publishes original articles on the function of the nervous system. All levels of function are included, from the membrane and cell to systems and behavior. Experimental approaches include molecular neurobiology, cell culture and slice preparations, membrane physiology, developmental neurobiology, functional neuroanatomy, neurochemistry, neuropharmacology, systems electrophysiology, imaging and mapping techniques, and behavioral analysis. Experimental preparations may be invertebrate or vertebrate species, including humans. Theoretical studies are acceptable if they are tied closely to the interpretation of experimental data and elucidate principles of broad interest.
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