Distant Metastasis of Merkel Cell Carcinoma: A Descriptive Study.

IF 2.3 4区 医学 Q2 DERMATOLOGY
Clara Muntaner-Virgili, Júlia Boronat-Cucarull, Josep Ramon Ferreres, Marta Gamissans, Joaquim Marcoval, Davinia Fernández-Calvo, Rosa María Penín, Josep Bermejo, Lia Huesa-Barceló, Sergio Manzano-Mora, Eric Ruzafa-Martínez, María Teresa Bajen-Lázaro, Ana Benítez-Segura, Paula Cecilia Notta, Laura Jiménez-Colomo, Juan Martín-Liberal, Pablo Araguas-Mora, Marc Juárez-Lozano, Isabel Linares-Galiana
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引用次数: 0

Abstract

Introduction: There are few studies on the pattern of distant spread of Merkel cell carcinoma (MCC).

Objectives: To analyse the most frequent locations of distant metastases from MCC and their possible relationship with the location of the primary tumour.

Methods: Patients diagnosed with cutaneous MCC between 1988 and 2022 were included in the study. The locations of the first metastases detected were recorded, both at tumour diagnosis and during follow-up after initial treatment.

Results: One hundred patients were diagnosed with MCC. Distant metastases were detected in 31 patients (seven at diagnosis and 24 during follow-up), with a total of 52 locations: 17 non-regional lymph node metastases, 10 bone, seven liver, six lung, four non-regional cutaneous/subcutaneous, three pancreatic, two adrenal, two pharyngeal, and one mammary. No patient developed metastasis to the central nervous system. Recurrences occurred in 84% of patients before two years of follow-up. Although differences were not significant, MCCs located in the extremities tended to metastasize to extra-regional lymph nodes and those in the head and neck to bone, liver, and lung.

Conclusions: MCC produces metastases mainly in non-regional lymph nodes, bone, liver, and lung. Given its high frequency (1/3 of patients), we consider performing scheduled imaging tests during the first two years of follow-up advisable. Specific imaging tests for central nervous system could be reserved for patients with neurological symptoms.

默克尔细胞癌的远处转移:一项描述性研究。
导读:目前关于默克尔细胞癌(MCC)远处扩散模式的研究很少。目的:分析MCC远处转移的最常见部位及其与原发肿瘤位置的可能关系。方法:1988年至2022年间诊断为皮肤MCC的患者纳入研究。在肿瘤诊断和初始治疗后随访期间记录首次转移的位置。结果:100例患者被诊断为MCC。31例患者发现远处转移(诊断时7例,随访时24例),共52个部位:17例非区域淋巴结转移,10例骨转移,7例肝转移,6例肺转移,4例非区域皮肤/皮下转移,3例胰腺转移,2例肾上腺转移,2例咽部转移,1例乳腺转移。没有患者发生中枢神经系统转移。在两年的随访前,84%的患者复发。尽管差异不显著,但位于四肢的mcc倾向于转移到区域外淋巴结,头颈部的mcc倾向于转移到骨、肝和肺。结论:MCC主要在非区域淋巴结、骨、肝和肺发生转移。鉴于其高频率(三分之一的患者),我们认为在随访的头两年进行定期影像学检查是可取的。中枢神经系统的特异性影像学检查可保留给有神经系统症状的患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
1.40
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217
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