Serum Zonulin and Its Role in Rosacea Pathogenesis: A Comprehensive Estimation Study.

IF 2.3 4区 医学 Q2 DERMATOLOGY
Fatma H Shabaka, Laila A Rashed, Mona S Ali, Aya A Salama
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Abstract

Introduction: Rosacea is a chronic inflammatory skin disorder distinguished by recurrent episodes of inflammatory papules, persistent erythema, facial flushing, pustules, and telangiectasia. Any disturbance in the gut microbiome could influence the immune system equilibrium in rosacea by releasing zonulin, leading to increased intestinal permeability and the passage of many microbes into the circulation, causing inflammation.

Objectives: We aimed to estimate the serum zonulin levels in cases with rosacea compared with healthy controls. Some fecal bacteria were investigated in an attempt to find a relationship between gut microbiome and rosacea.

Methods: This case-control study was performed on 42 participants aged above 18 years: 21 patients with a clinical diagnosis of rosacea approved by dermoscopy and 21 healthy individuals as controls. The serum zonulin level was estimated by the enzyme-linked immunosorbent assay technique, and some gut microbiomes were investigated using real-time quantitative PCR.

Results: There was a statistically significantly higher serum zonulin level in rosacea cases than in controls. There was a statistically significant elevation in Bacteroides and Lactobacillus gut microbiomes in rosacea patients compared to controls, while there was no statistically significant increase in Fusobacterium microbiome in patients. Zonulin levels did not show a significant correlation with gut microbiome.

Conclusions: Serum zonulin measurement can be used as a discriminating marker between rosacea and healthy controls, due to getting a specific cut-off point in ROC analysis with the highest specificity and sensitivity (100% and 100%, respectively). Gut microbial dysbiosis could play a valuable role in the disease pathogenesis.

血清Zonulin及其在酒渣鼻发病中的作用:一项综合评估研究。
酒渣鼻是一种慢性炎症性皮肤病,以反复发作的炎性丘疹、持续性红斑、面部潮红、脓疱和毛细血管扩张为特征。肠道微生物群的任何紊乱都可能通过释放带蛋白影响酒渣鼻的免疫系统平衡,导致肠道通透性增加,许多微生物进入循环,引起炎症。目的:我们旨在评估酒渣鼻患者与健康对照者的血清带蛋白水平。研究了一些粪便细菌,试图找到肠道微生物群与酒渣鼻之间的关系。方法:本病例对照研究纳入42例18岁以上的受试者,其中21例经皮肤镜检查证实为酒渣鼻的患者,21例健康人作为对照。采用酶联免疫吸附法测定血清zonulin水平,采用实时定量PCR检测部分肠道微生物组。结果:酒渣鼻患者血清带蛋白水平明显高于对照组。与对照组相比,酒渣鼻患者肠道菌群中拟杆菌和乳酸菌群的升高具有统计学意义,而患者中梭杆菌群的增加没有统计学意义。Zonulin水平与肠道微生物组无显著相关性。结论:血清带蛋白测定可作为酒渣鼻与健康对照的鉴别指标,在ROC分析中可获得特异性和敏感性最高的分界点(分别为100%和100%)。肠道微生物生态失调可能在疾病发病机制中发挥重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
217
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