Chondrodermatitis Nodularis Helicis: Association with Higher Risk of Multimorbidity and Mortality in Middle-Aged Individuals and Implications for Prevention. An Observational Multicenter Retrospective Case-Control Investigation in Northern Spain.

IF 2.3 4区 医学 Q2 DERMATOLOGY
Francisco Vázquez-López, Luis Requena, Cristina Galache, Carla Díaz-Louzao, Marcos A González-López
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Abstract

Introduction: Previous studies have independently linked chondrodermatitis nodularis (CN) with vascular injury, tobacco smoking, and diabetes, particularly in adult patients with early onset lesions.

Objectives: To build on previous research by investigating survival and frequency of comorbidities in adult patients diagnosed with premature CN lesions (<61 years).

Methods: We conducted a retrospective multicenter case-control observational study focused on individuals diagnosed with CN before the age of 61. Participants were further categorized into those diagnosed before 46 years and those diagnosed between ages 46 and 60 years. We evaluated the frequency of cancer, chronic obstructive lung disease, severe liver disease, diabetes mellitus, HIV infection, arterial disease, hypertension, dyslipidemia, multimorbidity, and tobacco smoking as well as survival rates. Statistical analysis included univariate analysis (including Holm-Bonferroni test), Kaplan-Meier plot estimation with log-rank test, and multivariate Cox analysis.

Results: Patients diagnosed with CN between ages 46 and <61 years showed significantly greater multimorbidity (Holm-Bonferroni test, P=0.00007 < 0.00122) and higher mortality rates compared to controls (log-rank test, P=0.006). Multivariate Cox analysis revealed an adjusted HR of 2.75 (95% CI: 1.36-5.54, P=0.005).

Conclusions: The novel finding of this retrospective multicenter study is that a diagnosis of CN in middle-aged patients could be a marker of elevated risk of systemic comorbidity and mortality. These results highlight the need for prospective studies to confirm these associations. Meanwhile, clinicians should be aware that emphasizing healthy lifestyle choices of patients with CN may have an important preventive value.

Abstract Image

Abstract Image

螺旋结节性软骨皮炎:与中年人群多病和死亡率增高的关系及其预防意义西班牙北部一项观察性多中心回顾性病例对照调查。
先前的研究独立地将结节性软骨皮炎(CN)与血管损伤、吸烟和糖尿病联系起来,特别是在早期病变的成人患者中。目的:在以往研究的基础上,调查诊断为CN过早病变的成人患者的生存率和合并症的频率。方法:我们进行了一项回顾性多中心病例对照观察性研究,重点研究了61岁之前诊断为CN的个体。参与者被进一步分为46岁之前诊断的和46岁到60岁之间诊断的。我们评估了癌症、慢性阻塞性肺病、严重肝病、糖尿病、HIV感染、动脉疾病、高血压、血脂异常、多病和吸烟的频率以及生存率。统计分析包括单因素分析(包括Holm-Bonferroni检验)、Kaplan-Meier图估计和log-rank检验、多因素Cox分析。结论:这项回顾性多中心研究的新发现是,中年患者诊断为CN可能是全身性合并症和死亡风险升高的标志。这些结果强调需要前瞻性研究来证实这些关联。同时,临床医生应该意识到,强调CN患者健康生活方式的选择可能具有重要的预防价值。
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CiteScore
1.40
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