Oxygenation indices and echocardiographic markers of pulmonary hypertension and ventricular dysfunction in congenital diaphragmatic hernia.

IF 2.3 4区 医学 Q2 PEDIATRICS
Talal Altamimi, Mohammed Almahdi, Saleh S Algarni, Saad Alshreedah, Naif Alotaibi, Mohammed Sufyani, Mohanned Alrahili, Abdulrahman Almehaid, Ibrahim Ali, Saif Alsaif, Kamal Ali
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引用次数: 0

Abstract

Objectives: To evaluate the relationship between early oxygenation indices (oxygenation index (OI) and oxygen saturation index (OSI)) and echocardiographic markers of ventricular dysfunction and pulmonary hypertension in neonates with congenital diaphragmatic hernia (CDH).

Design: Single-centre retrospective cohort study.

Setting: Level III neonatal intensive care unit at King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Patients: A total of 47 neonates with CDH admitted between 2016 and 2024 were included. Infants with major congenital heart disease or chromosomal anomalies were excluded.

Main outcome measures: Correlation of OI and OSI within the first 48 hours with echocardiographic markers of ventricular function, pulmonary hypertension and Vasoactive-Inotropic Score (VIS).

Results: Among 47 infants, survival was 70%. Survivors had higher left ventricular ejection fraction (M-mode: 61% vs 40%, p=0.010) and more preserved speckle-tracking strain (-17% vs -11%, p=0.006). Non-survivors had elevated right ventricular systolic pressure (RVSP) (68 vs 40 mm Hg, p=0.001), greater systolic eccentricity index (1.9 vs 1.4, p=0.002) and a higher percentage of right-to-left patent ductus arteriosus (PDA) shunting (50% vs 11%, p<0.001). Higher best, mean and highest OI and OSI values were significantly correlated with impaired ventricular function, elevated RVSP and greater right-to-left PDA flow. VIS was strongly correlated with all oxygenation indices, with the strongest correlations observed for mean OSI (r=0.851, p<0.001) and mean OI (r=0.812, p<0.001). Receiver operating characteristic analysis showed that RVSP had the strongest predictive accuracy for survival (area under the curve (AUC) 0.985, sensitivity 98% and specificity 97%), followed by the percentage of right-to-left PDA shunting (AUC 0.847) and left ventricular output (AUC 0.825).

Conclusions: Elevated oxygenation indices within the first 48 hours are associated with biventricular dysfunction, pulmonary hypertension and higher inotropic support requirements in CDH. Integration of early oxygenation measures and echocardiographic assessment may enhance risk stratification and guide therapeutic decision-making.

先天性膈疝肺动脉高压和心室功能障碍的氧合指数和超声心动图指标。
目的:探讨新生儿先天性膈疝(CDH)早期氧合指数(oxygenation index, OI)和氧饱和度指数(oxygen saturation index, OSI)与室性功能障碍和肺动脉高压超声心动图指标的关系。设计:单中心回顾性队列研究。地点:沙特阿拉伯利雅得阿卜杜勒阿齐兹国王医疗城三级新生儿重症监护病房。患者:共纳入2016 - 2024年间收治的47例新生儿CDH。排除有重大先天性心脏病或染色体异常的婴儿。主要结局指标:前48小时内OI和OSI与心室功能、肺动脉高压和血管活性-肌力评分(VIS)超声心动图标志物的相关性。结果:47例患儿生存率为70%。幸存者有较高的左心室射血分数(m型:61% vs 40%, p=0.010)和保存较多的斑点跟踪菌株(-17% vs -11%, p=0.006)。非幸存者右心室收缩压(RVSP)升高(68 vs 40 mm Hg, p=0.001),收缩偏心率指数更高(1.9 vs 1.4, p=0.002),右至左动脉导管未闭(PDA)分流比例更高(50% vs 11%)。结论:前48小时内氧合指数升高与CDH双室功能障碍、肺动脉高压和肌力支持需求增加有关。早期氧合测量和超声心动图评估的结合可以加强风险分层和指导治疗决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMJ Paediatrics Open
BMJ Paediatrics Open Medicine-Pediatrics, Perinatology and Child Health
CiteScore
4.10
自引率
3.80%
发文量
124
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