A diffusion-driven phase-field model for simulation of glioma growth.

IF 1.6 4区医学 Q3 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Computer Methods in Biomechanics and Biomedical Engineering Pub Date : 2025-08-09 DOI:10.1080/10255842.2025.2544792

Meisam Soleimani, Harold F Hounchonou, Joachim K Krauss, Matthias Simon, Philipp Junker, Majid Esmaeilzadeh

引用次数: 0

Abstract

Modelling glioma remains a critical area of research due to its poor prognosis. Phase-field modelling is an effective computational approach to simulate the dynamics of biological systems, including tumor growth like glioma. Here, the growth of a tumor is studied in the proximity of a blood artery that nourishes the tumor. The mathematical model reflects a diffusion-driven growth using a phase-field approach coupled with mechanical deformation. The numerical implementation of the mathematical model is realized in an FEM framework. Several numerical examples are provided to show the applicability of the model especially in clinical practices.

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用于模拟胶质瘤生长的扩散驱动相场模型。

由于胶质瘤预后不良，其建模仍然是一个重要的研究领域。相场建模是一种有效的模拟生物系统动力学的计算方法，包括胶质瘤等肿瘤的生长。在这里，肿瘤的生长在滋养肿瘤的血动脉附近被研究。数学模型反映了扩散驱动的生长，使用相场方法与机械变形相结合。在有限元框架中实现了数学模型的数值实现。通过数值算例说明了该模型在临床应用中的适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Computer Methods in Biomechanics and Biomedical Engineering 工程技术-工程：生物医学

CiteScore

4.10

自引率

6.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： The primary aims of Computer Methods in Biomechanics and Biomedical Engineering are to provide a means of communicating the advances being made in the areas of biomechanics and biomedical engineering and to stimulate interest in the continually emerging computer based technologies which are being applied in these multidisciplinary subjects. Computer Methods in Biomechanics and Biomedical Engineering will also provide a focus for the importance of integrating the disciplines of engineering with medical technology and clinical expertise. Such integration will have a major impact on health care in the future.