The role of pattern electroretinogram and pattern visual-evoked potentials in ocular hypertension.

IF 2.9 4区 医学 Q2 OPHTHALMOLOGY
Documenta Ophthalmologica Pub Date : 2025-10-01 Epub Date: 2025-08-10 DOI:10.1007/s10633-025-10043-0
Di Zhang, Xin Xie, Tian Cheng, Taikang Yao, Yunqi Zhang, Sitong Pan, Lingge Suo
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引用次数: 0

Abstract

Purpose: To compare the pattern electroretinogram (PERG) and patterned visual evoked potential (PVEP) between ocular hypertension (OHT) and normal subjects.

Methods: This cross-sectional observational study included two groups: a control group (46 eyes from 23 subjects; mean age, 33.83 ± 9.10 years old) and an OHT group (34 eyes from 17 patients; mean age, 36.75 ± 11.00 years old). All OHT patients had normal visual fields and normal optic disc appearances but had elevated intraocular pressures. The PERG was recorded using counter-phasing 48' checkerboard patterns, and amplitudes and latencies of P50 and N95 were documented. The PVEP was recorded using checkerboard pattern reversal stimuli with large 60' and small 15' check sizes, and the amplitudes and latencies of the P100 peaks were documented. Group differences were compared, and receiver operating characteristic analyses were performed to evaluate the diagnostic performance of these parameters.

Results: The peak latencies of P50 and N95 in the PERG were significantly prolonged in the OHT group compared to the control group (p = 0.002 and p = 0.041, respectively), while the amplitudes of P50 and N95 were significantly reduced (p < 0.001 for both). Regarding PVEP results, the P100 peak latencies for both 60' check and 15' check stimuli were significantly longer in the OHT group (p < 0.001 for both), and the P100 amplitudes were significantly lower (p = 0.001 and p = 0.017, respectively). Furthermore, the P50 and N95 amplitudes in PERG, and the P100 peak latency in PVEP, all demonstrated good diagnostic ability (AUC > 0.8, p < 0.001).

Conclusion: Abnormalities in PERG and PVEP amplitudes and timing were detected in OHT patients. The P50 and N95 amplitudes in PERG, as well as the P100 peak latency in PVEP, exhibited good ability to differentiate OHT patients from normal subjects.

型视网膜电图和型视诱发电位在高眼压中的作用。
目的:比较高眼压(OHT)与正常人视网膜电图(PERG)和视觉诱发电位(PVEP)的差异。方法:本横断面观察性研究分为两组:对照组(23名受试者46只眼);平均年龄33.83±9.10岁),OHT组(17例34眼;平均年龄36.75±11.00岁)。所有OHT患者视野和视盘外观正常,但眼压升高。用48'棋盘图记录PERG,记录P50和N95的振幅和潜伏期。采用棋盘图案反转刺激(大60‘和小15’)记录PVEP,记录P100峰值的振幅和潜伏期。比较各组差异,并进行受试者操作特征分析以评估这些参数的诊断性能。结果:与对照组相比,OHT组PERG中P50和N95的峰潜伏期明显延长(p = 0.002和p = 0.041), P50和N95的波幅明显降低(p = 0.8, p)。结论:OHT患者PERG和PVEP波幅和时间存在异常。PERG的P50和N95振幅以及PVEP的P100峰潜伏期表现出良好的区分OHT患者与正常受试者的能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Documenta Ophthalmologica
Documenta Ophthalmologica 医学-眼科学
CiteScore
3.50
自引率
21.40%
发文量
46
审稿时长
>12 weeks
期刊介绍: Documenta Ophthalmologica is an official publication of the International Society for Clinical Electrophysiology of Vision. The purpose of the journal is to promote the understanding and application of clinical electrophysiology of vision. Documenta Ophthalmologica will publish reviews, research articles, technical notes, brief reports and case studies which inform the readers about basic and clinical sciences related to visual electrodiagnosis and means to improve diagnosis and clinical management of patients using visual electrophysiology. Studies may involve animals or humans. In either case appropriate care must be taken to follow the Declaration of Helsinki for human subject or appropriate humane standards of animal care (e.g., the ARVO standards on Animal Care and Use).
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