Carcinogenicity of some metals evaluated by the IARC Monographs: A synopsis of the evaluations of arsenic, cadmium, cobalt, and antimony

IF 3.4 3区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicology and applied pharmacology Pub Date : 2025-08-06 DOI:10.1016/j.taap.2025.117506

Aline de Conti , Federica Madia, Mary K. Schubauer-Berigan, Lamia Benbrahim-Tallaa

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引用次数: 0

Abstract

Metals represent a major area of concern due to their extensive industrial applications, environmental persistence, and well-documented adverse health effects. Notably, metals (and metalloids) such as arsenic, cadmium, beryllium, chromium, cobalt, lead, and nickel are known for their toxicity and carcinogenic potential, raising significant public health concerns. Human exposure to these metals occurs through different routes, posing both environmental and workplace hazards. The Monographs programme of the International Agency for Research on Cancer (IARC) plays a critical role in identifying carcinogenic hazards to humans, providing a robust scientific foundation for global actions to prevent cancer. This review focuses on selected metals and metalloids: arsenic, cadmium, cobalt, and antimony, emphasizing how the IARC evaluation process considers the biological properties of the metals and their compounds, and the evidence from experimental animal studies and mechanistic data, including the application of the key characteristics of carcinogens (KCs) framework, in determining carcinogenic potential. The IARC Monographs contribute to a comprehensive understanding of metal-induced carcinogenicity and reinforce the importance of systematic, evidence-based approaches to inform public health interventions and regulatory decision-making.

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国际癌症研究机构专著评估的某些金属的致癌性：砷、镉、钴和锑的评估摘要。

金属由于其广泛的工业应用、环境持久性和有案可查的不利健康影响而成为一个主要关注领域。值得注意的是，砷、镉、铍、铬、钴、铅和镍等金属（和类金属）因其毒性和致癌潜力而闻名，引起了重大的公共卫生问题。人体通过不同途径接触到这些金属，对环境和工作场所都有危害。国际癌症研究机构（IARC）的专著计划在确定对人类的致癌危害方面发挥着关键作用，为全球预防癌症行动提供了坚实的科学基础。本综述侧重于选定的金属和类金属：砷、镉、钴和锑，强调国际癌症研究机构的评估过程如何考虑金属及其化合物的生物学特性，以及来自实验动物研究和机制数据的证据，包括致癌物关键特征（KCs）框架的应用，以确定致癌潜力。国际癌症研究机构的专著有助于全面了解金属诱发的致癌性，并强调了为公共卫生干预和监管决策提供信息的系统性、循证方法的重要性。

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来源期刊

Toxicology and applied pharmacology 医学-毒理学

CiteScore

6.80

自引率

2.60%

发文量

309

审稿时长

32 days

期刊介绍： Toxicology and Applied Pharmacology publishes original scientific research of relevance to animals or humans pertaining to the action of chemicals, drugs, or chemically-defined natural products. Regular articles address mechanistic approaches to physiological, pharmacologic, biochemical, cellular, or molecular understanding of toxicologic/pathologic lesions and to methods used to describe these responses. Safety Science articles address outstanding state-of-the-art preclinical and human translational characterization of drug and chemical safety employing cutting-edge science. Highly significant Regulatory Safety Science articles will also be considered in this category. Papers concerned with alternatives to the use of experimental animals are encouraged. Short articles report on high impact studies of broad interest to readers of TAAP that would benefit from rapid publication. These articles should contain no more than a combined total of four figures and tables. Authors should include in their cover letter the justification for consideration of their manuscript as a short article.