Crocus sativus and Neurological Health: A Review on Depression and Impaired Neurogenesis.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current pharmaceutical design Pub Date : 2025-08-05 DOI:10.2174/0113816128380974250716232813

Ayesha Sultana, Abdul Rahman Shafeeh, Mohammed Gulzar Ahmed, Abdul Rahamanulla, Gyas Khan, Md Sadique Hussain

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Abstract

Crocus sativus (saffron) is a valuable medicinal plant with a rich phytochemical profile, including bioactive carotenoids, flavonoids, and terpenoids. The key constituents of saffron-crocin, crocetin, picrocrocin, and safranal-exhibit potent neuroprotective properties, with crocin, a water-soluble carotenoid, playing a crucial role in promoting neurogenesis and mitigating depressive symptoms. Depression, affecting approximately 280 million individuals globally (WHO, 2023), is closely associated with impaired neurogenesis, highlighting the need for novel treatment strategies. Crocus sativus, particularly in its nanotherapeutic form, offers promise in the treatment of depression by effectively crossing the blood-brain barrier and modulating neurotransmitter systems. In addition to its carotenoids, saffron contains flavonoids, such as kaempferol and quercetin derivatives, which contribute to its antioxidant and anti-inflammatory activities. This review explores the phytochemical composition of Crocus sativus, its role in neurogenesis, and its potential as a therapeutic agent for depression and neurodegenerative disorders.

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藏红花与神经系统健康：抑郁症与神经发生障碍的研究进展。

藏红花是一种有价值的药用植物，具有丰富的植物化学成分，包括生物活性类胡萝卜素、类黄酮和萜类化合物。藏红花的主要成分——藏红花素、藏红花素、微藏红花素和藏红花那——具有有效的神经保护特性，其中藏红花素是一种水溶性类胡萝卜素，在促进神经发生和减轻抑郁症状方面起着至关重要的作用。抑郁症影响全球约2.8亿人（世卫组织，2023年），与神经发生受损密切相关，这突出表明需要新的治疗策略。藏红花，特别是其纳米治疗形式，通过有效地穿越血脑屏障和调节神经递质系统，为治疗抑郁症提供了希望。除了类胡萝卜素，藏红花还含有类黄酮，如山奈酚和槲皮素衍生物，有助于其抗氧化和抗炎活性。本文综述了藏红花的植物化学成分及其在神经发生中的作用，以及其作为抑郁症和神经退行性疾病治疗剂的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current pharmaceutical design 医学-药学

CiteScore

6.30

自引率

0.00%

发文量

302

审稿时长

2 months

期刊介绍： Current Pharmaceutical Design publishes timely in-depth reviews and research articles from leading pharmaceutical researchers in the field, covering all aspects of current research in rational drug design. Each issue is devoted to a single major therapeutic area guest edited by an acknowledged authority in the field. Each thematic issue of Current Pharmaceutical Design covers all subject areas of major importance to modern drug design including: medicinal chemistry, pharmacology, drug targets and disease mechanism.