The effect of hypervigilance on visual working memory in insomnia disorder: Evidence from ERP study

IF 3.7 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-08-05 DOI:10.1016/j.brainresbull.2025.111503

Chao Yang , Junhua Mei , Xinhua Song , Jinzhen Jiang , Cancheng Li , Anan Ping , Xingke Wang , Shaodi Wang , Sheng Yang , Yingchao Jiang , Kun Wang , Yushan Bian , Yan Wang , Guohua Chen , Changming Wang , Xiaoli Li

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引用次数: 0

Abstract

Background

This study investigates the impact of hypervigilance on visual working memory in individuals with insomnia disorder using event-related potentials (ERP) and time-frequency analysis.

Methods

A total of 45 insomnia disorder (ID) patients and 43 healthy controls (HC) participated in a visual working memory task that involved encoding, maintaining, and retrieving visual stimuli (S1 and S2) of blurred and clear pictures. ERP components and frequency bands were analyzed across these stages.

Results

The ID group had significantly altered ERP amplitudes and increased theta and beta activity across all stages compared to the HC group, indicating hypervigilance and cognitive resource consumption during working memory processing. In the encoding stage, P100 and N170 amplitudes were significantly correlated with insomnia severity (ISI), while P200 amplitude was linked to HAMA score. During the maintenance stage, CNV amplitude and increased theta power were associated with sustained attention, which correlated with ISI scores, reflecting the burden of maintaining attention in hypervigilance states. In the retrieval stage, the ID group showed reduced P300 amplitudes but increased LPC amplitudes, highlighting their struggle with memory updating and complex cognitive processing under hypervigilance states.

Conclusion

These findings suggest that ID patients exhibit hypervigilance, which affects the efficiency of visual working memory, impairs attention regulation, and increases cognitive load during tasks. Understanding these mechanisms may provide insights for clinical interventions aimed at improving cognitive function in ID patients.

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高警觉性对失眠患者视觉工作记忆的影响：来自ERP研究的证据。

背景：本研究利用事件相关电位（ERP）和时频分析探讨了高警觉性对失眠症患者视觉工作记忆的影响。方法：45例失眠症（ID）患者和43例健康对照（HC）参与视觉工作记忆任务，该任务涉及模糊和清晰图像的视觉刺激（S1和S2）的编码、维持和检索。分析了这些阶段的ERP成分和频带。结果：与HC组相比，ID组在所有阶段都显著改变了ERP振幅，增加了θ和β活动，表明工作记忆加工过程中的高度警觉性和认知资源消耗。编码阶段，P100和N170幅值与失眠严重程度（ISI）显著相关，P200幅值与HAMA评分显著相关。在维持阶段，CNV振幅和θ波功率的增加与持续注意相关，与ISI评分相关，反映了高警觉状态下维持注意的负担。在检索阶段，ID组的P300幅值降低，LPC幅值升高，突出了他们在高警觉性状态下记忆更新和复杂认知加工的挣扎。结论：本研究提示ID患者表现出高警觉性，影响了视觉工作记忆的效率，损害了注意力调节，增加了任务中的认知负荷。了解这些机制可能为旨在改善ID患者认知功能的临床干预提供见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.