Modification of reported antibiotic susceptibility testing according to the EUCAST recommendations: Evaluation of the appropriateness of antibiotic prescriptions in a university hospital.

IF 2.2 4区医学 Q2 INFECTIOUS DISEASES

Infectious diseases now Pub Date : 2025-08-06 DOI:10.1016/j.idnow.2025.105130

C About, F Meyer, M Simon, E Jeanbert, B Demore, A Charmillon

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Abstract

Objectives: In January 2022, EUCAST guidelines recommending replacement of the "intermediate" category with a "susceptible, increased exposure" (SFP) category were implemented in our hospital. We aimed to assess the impact of these changes on antibiotic prescriptions for Pseudomonas aeruginosa and Staphylococcus aureus infections.

Methods: This retrospective before-after study included adult inpatients with monobacterial infections between March-August 2021 (BEFORE) and March-August 2022 (AFTER). Antibiotic use and relevance were compared. Meropenem was masked when imipenem was categorized as SFP.

Results: We included 240 antibiotic susceptibility tests (195 patients). Infectious disease consultations increased significantly during implementation (53.0 % vs. 28.9 %, p = 0.0005). Meropenem prescriptions for P. aeruginosa declined (13.8 %-6.2 %), while high-dose regimens for SFP antibiotics likewise decreased (50.0 %-35.4 %). Overall, prescription appropriateness remained high (>92 %).

Conclusion: The introduction of SFP reporting was associated with increased ID consultation and a trend toward reduced broad-spectrum use, highlighting a need for targeted prescriber education.

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根据EUCAST建议修改报告的抗生素敏感性试验：评价大学医院抗生素处方的适宜性。

目的：2022年1月，EUCAST指南建议将“中间”类别替换为“易感、暴露增加”（SFP）类别在我院实施。我们的目的是评估这些变化对铜绿假单胞菌和金黄色葡萄球菌感染抗生素处方的影响。方法：本回顾性研究纳入了2021年3月至8月（BEFORE）和2022年3月至8月（AFTER）期间住院的成人单细菌感染患者。比较抗生素使用及相关性。当亚胺培南被归类为SFP时，美罗培南被掩盖。结果：纳入抗生素敏感性试验240例（195例）。传染病咨询在实施期间显著增加（53.0 % vs. 28.9 %,p = 0.0005）。铜绿假单胞菌的美罗培南处方减少了（13.8% %-6.2 %），而SFP抗生素的高剂量方案同样减少了（50.0% %- 35.4% %）。总体而言，处方的适宜性仍然很高（bbb92 %）。结论：SFP报告的引入与增加的ID咨询和减少广谱使用的趋势有关，突出了对处方者进行针对性教育的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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