Interaction Between Age and Tumor Stage in Survival Outcomes of Patients With Mantle Cell Lymphoma.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL
Ayrton Bangolo, Behzad Amoozgar, Vignesh K Nagesh, Kyra McGrath, Swapnika Mallipeddi, Samantha Cash, Ankit Sandilya, Rakshanda Banu, Frantz R Martine, Sarvarinder Gill, Lili Zhang, Shafia Naeem, Pujita Mallampalli, Arun Ram, Dessislava Papantoniou, Shallot Nareeba, Kwangha Baek, Urveesh Sharma, Gopal Mondal, Kausar Bano, Mary Gad, Priya R Rokade, Monica M Kharat, Aditya Dodhia, Snehal Goud, Sahiti Gavva, Eyasu G Aduna, Zaed S Siddiqui, Aadi R Palvia, Arjuninder Singh, Akaash Nayak, Krishna P Jakkula, Achint Jethi, Neeharika Thota, Simcha Weissman
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引用次数: 0

Abstract

Background: Mantle Cell Lymphoma (MCL) is a rare and aggressive subtype of non-Hodgkin lymphoma. This study explores the demographic and clinicopathologic characteristics of 746 MCL patients diagnosed in the United States between 2000 and 2015, focusing on the interaction between age and tumor stage.

Methods: Using SEER database data, this retrospective cohort study analyzes demographic and clinical variables like age, gender, stage, treatment, and marital status. Mortality risks were assessed using Cox proportional hazard regression models to identify predictors of overall mortality (OM) and cancer-specific mortality (CSM), emphasizing age-tumor stage interactions.

Results: Multivariate Cox regression identified age and advanced Ann Arbor stage (II, III, and IV) as critical predictors of increased OM and MCL-specific mortality. Patients aged 80+ had the highest mortality risks (OM HR = 3.93, 95 % CI 1.33-11.64; CSM HR = 4.02, 95 % CI 1.36-11.88). Marital status was significant, with widowed individuals experiencing elevated mortality (OM HR = 1.85, 95 % CI 1.28-2.68; CSM HR = 1.81, 95 % CI 1.26-2.61). Advanced staging combined with older age showed significant risk interactions, except for Stage III, which lacked age-related significance.

Conclusion: Age, tumor stage, and marital status strongly influence MCL outcomes, highlighting the need for personalized management strategies. Widowed status underscores the role of social support in survival. Tailored interventions, accounting for these factors, can improve patient outcomes. Further research is essential to clarify age-stage interactions and refine therapeutic approaches.

年龄和肿瘤分期对套细胞淋巴瘤患者生存结果的影响。
背景:套细胞淋巴瘤(MCL)是一种罕见的侵袭性非霍奇金淋巴瘤亚型。本研究探讨2000 - 2015年美国746例MCL患者的人口学和临床病理特征,重点研究年龄与肿瘤分期之间的相互作用。方法:采用SEER数据库数据,本回顾性队列研究分析人口统计学和临床变量,如年龄、性别、分期、治疗和婚姻状况。使用Cox比例风险回归模型评估死亡风险,以确定总死亡率(OM)和癌症特异性死亡率(CSM)的预测因子,强调年龄-肿瘤分期的相互作用。结果:多变量Cox回归确定年龄和晚期安娜堡期(II、III和IV)是OM和mcl特异性死亡率增加的关键预测因素。80岁以上患者死亡风险最高(OM HR = 3.93, 95% CI 1.33-11.64;CSM hr = 4.02, 95% ci 1.36-11.88)。婚姻状况具有显著性,丧偶个体的死亡率升高(OM HR = 1.85, 95% CI 1.28-2.68;CSM hr = 1.81, 95% ci 1.26-2.61)。除了III期缺乏与年龄相关的显著性外,晚期与老年表现出显著的风险相互作用。结论:年龄、肿瘤分期和婚姻状况对MCL的预后有很大影响,需要个性化的治疗策略。丧偶地位强调了社会支持在生存中的作用。考虑到这些因素,量身定制的干预措施可以改善患者的预后。进一步的研究是必要的,以澄清年龄阶段的相互作用和完善的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
自引率
0.00%
发文量
106
审稿时长
17 weeks
期刊介绍: JCHIMP provides: up-to-date information in the field of Internal Medicine to community hospital medical professionals a platform for clinical faculty, residents, and medical students to publish research relevant to community hospital programs. Manuscripts that explore aspects of medicine at community hospitals welcome, including but not limited to: the best practices of community academic programs community hospital-based research opinion and insight from community hospital leadership and faculty the scholarly work of residents and medical students affiliated with community hospitals.
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