Ayrton Bangolo, Behzad Amoozgar, Vignesh K Nagesh, Kyra McGrath, Swapnika Mallipeddi, Samantha Cash, Ankit Sandilya, Rakshanda Banu, Frantz R Martine, Sarvarinder Gill, Lili Zhang, Shafia Naeem, Pujita Mallampalli, Arun Ram, Dessislava Papantoniou, Shallot Nareeba, Kwangha Baek, Urveesh Sharma, Gopal Mondal, Kausar Bano, Mary Gad, Priya R Rokade, Monica M Kharat, Aditya Dodhia, Snehal Goud, Sahiti Gavva, Eyasu G Aduna, Zaed S Siddiqui, Aadi R Palvia, Arjuninder Singh, Akaash Nayak, Krishna P Jakkula, Achint Jethi, Neeharika Thota, Simcha Weissman
{"title":"Interaction Between Age and Tumor Stage in Survival Outcomes of Patients With Mantle Cell Lymphoma.","authors":"Ayrton Bangolo, Behzad Amoozgar, Vignesh K Nagesh, Kyra McGrath, Swapnika Mallipeddi, Samantha Cash, Ankit Sandilya, Rakshanda Banu, Frantz R Martine, Sarvarinder Gill, Lili Zhang, Shafia Naeem, Pujita Mallampalli, Arun Ram, Dessislava Papantoniou, Shallot Nareeba, Kwangha Baek, Urveesh Sharma, Gopal Mondal, Kausar Bano, Mary Gad, Priya R Rokade, Monica M Kharat, Aditya Dodhia, Snehal Goud, Sahiti Gavva, Eyasu G Aduna, Zaed S Siddiqui, Aadi R Palvia, Arjuninder Singh, Akaash Nayak, Krishna P Jakkula, Achint Jethi, Neeharika Thota, Simcha Weissman","doi":"10.55729/2000-9666.1480","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Mantle Cell Lymphoma (MCL) is a rare and aggressive subtype of non-Hodgkin lymphoma. This study explores the demographic and clinicopathologic characteristics of 746 MCL patients diagnosed in the United States between 2000 and 2015, focusing on the interaction between age and tumor stage.</p><p><strong>Methods: </strong>Using SEER database data, this retrospective cohort study analyzes demographic and clinical variables like age, gender, stage, treatment, and marital status. Mortality risks were assessed using Cox proportional hazard regression models to identify predictors of overall mortality (OM) and cancer-specific mortality (CSM), emphasizing age-tumor stage interactions.</p><p><strong>Results: </strong>Multivariate Cox regression identified age and advanced Ann Arbor stage (II, III, and IV) as critical predictors of increased OM and MCL-specific mortality. Patients aged 80+ had the highest mortality risks (OM HR = 3.93, 95 % CI 1.33-11.64; CSM HR = 4.02, 95 % CI 1.36-11.88). Marital status was significant, with widowed individuals experiencing elevated mortality (OM HR = 1.85, 95 % CI 1.28-2.68; CSM HR = 1.81, 95 % CI 1.26-2.61). Advanced staging combined with older age showed significant risk interactions, except for Stage III, which lacked age-related significance.</p><p><strong>Conclusion: </strong>Age, tumor stage, and marital status strongly influence MCL outcomes, highlighting the need for personalized management strategies. Widowed status underscores the role of social support in survival. Tailored interventions, accounting for these factors, can improve patient outcomes. Further research is essential to clarify age-stage interactions and refine therapeutic approaches.</p>","PeriodicalId":15460,"journal":{"name":"Journal of Community Hospital Internal Medicine Perspectives","volume":"15 3","pages":"5-14"},"PeriodicalIF":0.6000,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313125/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Community Hospital Internal Medicine Perspectives","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.55729/2000-9666.1480","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Mantle Cell Lymphoma (MCL) is a rare and aggressive subtype of non-Hodgkin lymphoma. This study explores the demographic and clinicopathologic characteristics of 746 MCL patients diagnosed in the United States between 2000 and 2015, focusing on the interaction between age and tumor stage.
Methods: Using SEER database data, this retrospective cohort study analyzes demographic and clinical variables like age, gender, stage, treatment, and marital status. Mortality risks were assessed using Cox proportional hazard regression models to identify predictors of overall mortality (OM) and cancer-specific mortality (CSM), emphasizing age-tumor stage interactions.
Results: Multivariate Cox regression identified age and advanced Ann Arbor stage (II, III, and IV) as critical predictors of increased OM and MCL-specific mortality. Patients aged 80+ had the highest mortality risks (OM HR = 3.93, 95 % CI 1.33-11.64; CSM HR = 4.02, 95 % CI 1.36-11.88). Marital status was significant, with widowed individuals experiencing elevated mortality (OM HR = 1.85, 95 % CI 1.28-2.68; CSM HR = 1.81, 95 % CI 1.26-2.61). Advanced staging combined with older age showed significant risk interactions, except for Stage III, which lacked age-related significance.
Conclusion: Age, tumor stage, and marital status strongly influence MCL outcomes, highlighting the need for personalized management strategies. Widowed status underscores the role of social support in survival. Tailored interventions, accounting for these factors, can improve patient outcomes. Further research is essential to clarify age-stage interactions and refine therapeutic approaches.
期刊介绍:
JCHIMP provides: up-to-date information in the field of Internal Medicine to community hospital medical professionals a platform for clinical faculty, residents, and medical students to publish research relevant to community hospital programs. Manuscripts that explore aspects of medicine at community hospitals welcome, including but not limited to: the best practices of community academic programs community hospital-based research opinion and insight from community hospital leadership and faculty the scholarly work of residents and medical students affiliated with community hospitals.