Case With Refractory Myasthenia Gravis Caused by Pembrolizumab.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL
Bushra Amer, Fatima D Hawshab, Lateefah D Hawshab, Khaled M Darwesh
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引用次数: 0

Abstract

Nowadays, checkpoint inhibitors play a major role in the management of different types of cancers. However, we have seen variants of immune therapy-related adverse events, which usually are variables from fatigue, to neuropathy to severe devastating complications such as respiratory failure due to myasthenia gravis (MG), as we saw in our case. Our patient was started on pembrolizumab, and they developed severe respiratory failure attributed to MG after three weeks from treatment initiation. Also, the patient presented with myositis, mild myocarditis and hepatitis, which were all related to pembrolizumab.

Abstract Image

Abstract Image

派姆单抗致难治性重症肌无力1例。
如今,检查点抑制剂在不同类型癌症的治疗中发挥着重要作用。然而,我们已经看到了免疫治疗相关不良事件的变体,通常从疲劳到神经病变到严重的破坏性并发症,如重症肌无力(MG)引起的呼吸衰竭,就像我们在本病例中看到的那样。我们的患者开始使用派姆单抗,在开始治疗三周后出现MG引起的严重呼吸衰竭。此外,患者出现肌炎、轻度心肌炎和肝炎,均与派姆单抗有关。
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来源期刊
自引率
0.00%
发文量
106
审稿时长
17 weeks
期刊介绍: JCHIMP provides: up-to-date information in the field of Internal Medicine to community hospital medical professionals a platform for clinical faculty, residents, and medical students to publish research relevant to community hospital programs. Manuscripts that explore aspects of medicine at community hospitals welcome, including but not limited to: the best practices of community academic programs community hospital-based research opinion and insight from community hospital leadership and faculty the scholarly work of residents and medical students affiliated with community hospitals.
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