Volume analysis of hippocampus and amygdala subregions in patients with retinal detachment

IF 3.7 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-08-05 DOI:10.1016/j.brainresbull.2025.111498

Yuanyuan Wang, Feng Ouyang, Jie Liu, Zihe Xu, Lianjiang Lv, Meimei Yan, Jialu Chen, Zhijun Luo, Xianjun Zeng

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引用次数: 0

Abstract

Background

We aimed to investigate the pattern of atrophy in the hippocampus and amygdala subregions in patients with retinal detachment (RD) and its correlation with cognition and emotion.

Methods

The study recruited 32 patients diagnosed with RD alongside 33 healthy controls (HCs), carefully matched for sex and age. Magnetic resonance imaging (MRI) scans of all participants underwent automated segmentation to delineate hippocampal and amygdala subfields, utilizing FreeSurfer v6.0.

Results

In contrast to the HCs, RD patients exhibited noteworthy volumetric reductions in various regions, including cornu ammonis 1 (CA1)-head, molecular layer, dentate gyrus, and hippocampus-amygdala transition area bilaterally. This led to a collective decrease in the volume of the bilateral whole hippocampal head, right whole hippocampal body, and right entire hippocampus. In addition, the volume of Accessory-Basal-nucleus, Anterior-amygdaloid-area-AAA, and Corticoamygdaloid-transitio on the right side was also significantly reduced. Furthermore, the decrease in hippocampal and amygdala subfield volumes among RD patients showed a negative correlation with disease duration and HAMA score, while exhibiting a positive correlation with the axial length of eye and MoCA score.

Conclusion

These findings imply that alterations in the volume of hippocampal and amygdala subfields in RD patients are associated with emotional and cognitive dysfunction and may serve as biomarkers for predicting disease progression in RD patients.

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视网膜脱离患者海马和杏仁核亚区体积分析。

背景：我们旨在研究视网膜脱离（RD）患者海马和杏仁核亚区萎缩的模式及其与认知和情绪的关系。方法：该研究招募了32名诊断为RD的患者和33名健康对照（hc），他们的性别和年龄经过仔细匹配。所有参与者的磁共振成像（MRI）扫描使用FreeSurfer v6.0进行自动分割，以描绘海马和杏仁核子区。结果：与hc相比，RD患者在多个区域表现出明显的体积减少，包括锥体氨1 (CA1)-头部、分子层、齿状回和海马-杏仁核过渡区。这导致双侧整个海马头、右侧整个海马体和右侧整个海马体积集体减少。右侧附属基底核区、前杏仁核区aaa区、皮质杏仁核过渡区体积也明显减小。RD患者海马和杏仁核亚区体积的减少与病程和HAMA评分呈负相关，而与眼轴长和MoCA评分呈正相关。结论：这些发现表明，RD患者海马和杏仁核亚区体积的改变与情绪和认知功能障碍有关，并可能作为预测RD患者疾病进展的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.