The Value of FeNO and Peripheral Blood Eosinophils in Assessing Airway Eosinophilic Inflammation in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease.

IF 1.1 4区医学 Q4 CELL BIOLOGY

Cytopathology Pub Date : 2025-08-02 DOI:10.1111/cyt.70009

HongXu Zhang, MengYu Lian, Nafeisa Dilixiati, Jie Song, JingJing Yang, RuiYan Lin, JinXiang Wang

{"title":"The Value of FeNO and Peripheral Blood Eosinophils in Assessing Airway Eosinophilic Inflammation in Patients With Acute Exacerbations of Chronic Obstructive Pulmonary Disease.","authors":"HongXu Zhang, MengYu Lian, Nafeisa Dilixiati, Jie Song, JingJing Yang, RuiYan Lin, JinXiang Wang","doi":"10.1111/cyt.70009","DOIUrl":null,"url":null,"abstract":"Background: To evaluate the clinical value of fractional exhaled nitric oxide (FeNO) levels and peripheral blood eosinophil (EOS) counts and percentages in assessing airway eosinophilic inflammation in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).Methods: In total, 119 AECOPD patients were included in the study. Patients were divided based on the percentage of EOS in their sputum into the airway EOS inflammation group (29 patients) and the non-airway EOS inflammation group (90 patients). The diagnostic values of FeNO and peripheral blood EOS for detecting airway EOS inflammation in AECOPD patients were assessed.Results: The airway EOS inflammation group had higher peripheral blood EOS counts and percentages. FeNO, peripheral blood EOS counts and percentages were significantly correlated with sputum EOS percentages. ROC curve analysis showed that the optimal cut-off values for predicting airway EOS inflammation were 18.5 ppb for FeNO, with sensitivities and specificities of 76% and 61%, respectively; 0.335 × 109/L for peripheral blood EOS count, with sensitivities and specificities of 41% and 98%, respectively; and 3.56% for peripheral blood EOS percentage, with sensitivities and specificities of 59% and 86%, respectively.Conclusions: FeNO, peripheral blood EOS counts and percentages have a strong correlation with airway EOS inflammation. The levels of FeNO and peripheral blood EOS counts and percentages can effectively predict airway EOS inflammation in AECOPD patients.","PeriodicalId":55187,"journal":{"name":"Cytopathology","volume":" ","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cytopathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/cyt.70009","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: To evaluate the clinical value of fractional exhaled nitric oxide (FeNO) levels and peripheral blood eosinophil (EOS) counts and percentages in assessing airway eosinophilic inflammation in patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).

Methods: In total, 119 AECOPD patients were included in the study. Patients were divided based on the percentage of EOS in their sputum into the airway EOS inflammation group (29 patients) and the non-airway EOS inflammation group (90 patients). The diagnostic values of FeNO and peripheral blood EOS for detecting airway EOS inflammation in AECOPD patients were assessed.

Results: The airway EOS inflammation group had higher peripheral blood EOS counts and percentages. FeNO, peripheral blood EOS counts and percentages were significantly correlated with sputum EOS percentages. ROC curve analysis showed that the optimal cut-off values for predicting airway EOS inflammation were 18.5 ppb for FeNO, with sensitivities and specificities of 76% and 61%, respectively; 0.335 × 10⁹/L for peripheral blood EOS count, with sensitivities and specificities of 41% and 98%, respectively; and 3.56% for peripheral blood EOS percentage, with sensitivities and specificities of 59% and 86%, respectively.

Conclusions: FeNO, peripheral blood EOS counts and percentages have a strong correlation with airway EOS inflammation. The levels of FeNO and peripheral blood EOS counts and percentages can effectively predict airway EOS inflammation in AECOPD patients.

查看原文本刊更多论文

FeNO和外周血嗜酸性粒细胞在评估慢性阻塞性肺疾病急性加重患者气道嗜酸性粒细胞炎症中的价值

背景：探讨呼气一氧化氮分数（FeNO）水平和外周血嗜酸性粒细胞（EOS）计数及百分比在慢性阻塞性肺疾病（AECOPD）急性加重期患者气道嗜酸性粒细胞炎症评估中的临床价值。方法：共纳入119例AECOPD患者。根据痰液中EOS的百分比将患者分为气道EOS炎症组（29例）和非气道EOS炎症组（90例）。评价FeNO和外周血EOS对AECOPD患者气道EOS炎症的诊断价值。结果：气道EOS炎症组外周血EOS计数和百分比较高。FeNO、外周血EOS计数和百分比与痰EOS百分比显著相关。ROC曲线分析显示，FeNO预测气道EOS炎症的最佳临界值为18.5 ppb，敏感性和特异性分别为76%和61%；外周血EOS计数0.335 × 109/L，敏感性41%，特异性98%；外周血EOS百分比为3.56%，敏感性为59%，特异性为86%。结论：FeNO、外周血EOS计数及百分比与气道EOS炎症有较强相关性。FeNO水平和外周血EOS计数及百分比可有效预测AECOPD患者气道EOS炎症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cytopathology 生物-病理学

CiteScore

2.30

自引率

15.40%

发文量

107

审稿时长

6-12 weeks

期刊介绍： The aim of Cytopathology is to publish articles relating to those aspects of cytology which will increase our knowledge and understanding of the aetiology, diagnosis and management of human disease. It contains original articles and critical reviews on all aspects of clinical cytology in its broadest sense, including: gynaecological and non-gynaecological cytology; fine needle aspiration and screening strategy. Cytopathology welcomes papers and articles on: ultrastructural, histochemical and immunocytochemical studies of the cell; quantitative cytology and DNA hybridization as applied to cytological material.