Pre- and post-diagnosis dietary total antioxidant capacity and overall survival in patients with ovarian cancer: a prospective cohort study.

IF 3.8 2区医学 Q1 NUTRITION & DIETETICS

Nutrition Journal Pub Date : 2025-08-01 DOI:10.1186/s12937-025-01185-7

Dong-Hui Huang, Lei Wang, Xiao-Ying Li, Ying Qin, Fang-Hua Liu, Yi-Zi Li, He-Li Xu, Fan Cao, Lang Wu, Yi-Fan Wei, Song Gao, Ting-Ting Gong, Yu-Hong Zhao, Qi-Jun Wu

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引用次数: 0

Abstract

Background: The current study aims to investigate the association between dietary total antioxidant capacity (DTAC) and overall survival (OS) in patients with ovarian cancer (OC).

Methods: A validated 111-item food frequency questionnaire was used to assess their pre- and post-diagnosis dietary intake. DTAC is represented by ferric-reducing ability of plasma (FRAP), total oxygen radical absorbance capacity (TORAC), hydrophilic oxygen radical absorbance capacity (HORAC), lipophilic oxygen radical absorbance capacity (LORAC), and total phenolics (TP). The OS was determined by both passive and active follow-up.

Results: A total of 531 patients with OC was involved in this study. High post-diagnosis FRAP (HR_{T3 vs. T1}=0.65, 95%CI = 0.42-0.99), post-diagnosis TORAC (HR_{T3 vs. T1}=0.68, 95%CI = 0.47-0.98), and pre-diagnosis LORAC (HR_{T3 vs. T1}=0.62, 95%CI = 0.43-0.89) had statistically significant association with an improved OS. Additionally, increased DTAC consumption (FRAP: HR _Low-Medium=0.53, 95%CI = 0.30-0.95; FRAP: HR _Low-High=0.46, 95%CI = 0.23-0.93; LORAC: HR _Medium-High=0.50, 95%CI = 0.27-0.91), as well as maintaining high or medium DTAC consumption (TORAC: HR _{Medium-Medium}=0.46, 95%CI = 0.26-0.83; TORAC: HR _High-High=0.57, 95%CI = 0.34-0.96; LORAC: HR _High-Medium=0.43, 95%CI = 0.23-0.82), improved the OS in patients with OC.

Conclusions: Increased pre- and post-diagnosis DTAC intake, and maintaining moderate or high DTAC intake after diagnosis, may be associated with enhanced OS in patients with OC.

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卵巢癌患者诊断前后膳食总抗氧化能力和总生存率：一项前瞻性队列研究

背景：本研究旨在探讨卵巢癌（OC）患者膳食总抗氧化能力（DTAC）与总生存期（OS）之间的关系。方法：采用经验证的111项食物频率问卷对患者诊断前后的膳食摄入量进行评估。DTAC由血浆铁还原能力（FRAP）、总氧自由基吸收能力（TORAC）、亲水氧自由基吸收能力（HORAC）、亲脂氧自由基吸收能力（LORAC）和总酚类物质（TP）表示。通过被动随访和主动随访确定OS。结果：本研究共纳入531例OC患者。较高的诊断后FRAP （HRT3 vs. T1=0.65, 95%CI = 0.42-0.99）、诊断后TORAC （HRT3 vs. T1=0.68, 95%CI = 0.47-0.98）和诊断前LORAC （HRT3 vs. T1=0.62, 95%CI = 0.43-0.89）与OS改善有统计学意义。此外，DTAC消耗增加(FRAP: HR低-中=0.53,95%CI = 0.30-0.95；FRAP: HR Low-High=0.46, 95%CI = 0.23-0.93；LORAC: HR中-高=0.50,95%CI = 0.27-0.91)，以及维持高或中等DTAC消耗(TORAC: HR中-高=0.46,95%CI = 0.26-0.83；TORAC: HR High-High=0.57, 95%CI = 0.34-0.96；LORAC: HR高-中=0.43,95%CI = 0.23-0.82)改善了OC患者的OS。结论：诊断前和诊断后DTAC摄入量的增加，以及诊断后维持中等或高DTAC摄入量，可能与OC患者的OS增强有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutrition Journal NUTRITION & DIETETICS-

CiteScore

9.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： Nutrition Journal publishes surveillance, epidemiologic, and intervention research that sheds light on i) influences (e.g., familial, environmental) on eating patterns; ii) associations between eating patterns and health, and iii) strategies to improve eating patterns among populations. The journal also welcomes manuscripts reporting on the psychometric properties (e.g., validity, reliability) and feasibility of methods (e.g., for assessing dietary intake) for human nutrition research. In addition, study protocols for controlled trials and cohort studies, with an emphasis on methods for assessing dietary exposures and outcomes as well as intervention components, will be considered. Manuscripts that consider eating patterns holistically, as opposed to solely reductionist approaches that focus on specific dietary components in isolation, are encouraged. Also encouraged are papers that take a holistic or systems perspective in attempting to understand possible compensatory and differential effects of nutrition interventions. The journal does not consider animal studies. In addition to the influence of eating patterns for human health, we also invite research providing insights into the environmental sustainability of dietary practices. Again, a holistic perspective is encouraged, for example, through the consideration of how eating patterns might maximize both human and planetary health.