Association between triglyceride glucose index and atrial fibrillation: A systematic review and meta-analysis.

IF 1.5 4区医学 Q4 NUTRITION & DIETETICS

Asia Pacific journal of clinical nutrition Pub Date : 2025-08-01 DOI:10.6133/apjcn.202508_34(4).0002

Qiang Chen, Jianqiang Zhao, Wei Wang

{"title":"Association between triglyceride glucose index and atrial fibrillation: A systematic review and meta-analysis.","authors":"Qiang Chen, Jianqiang Zhao, Wei Wang","doi":"10.6133/apjcn.202508_34(4).0002","DOIUrl":null,"url":null,"abstract":"Background and objectives: Previous studies have demonstrated that insulin resistance (IR) is associated with atrial fibrillation (AF). As a reliable indicator of IR, the triglyceride glucose (TyG) index has been extensively studied in relation to AF. We aimed to investigate the relationship between the TyG index and AF through a systematic review and meta-analysis.Methods and study design: We systematically searched studies published up to August 2024 in online databases including PubMed, Embase, Web of Science, Wan-fang, and the China National Knowledge Internet database. Seventeen studies involving 57,213 patients were included in the analysis. A random-effects model and exposure-effect analysis were used to calculate the pooled effect estimate and compute the linear trend.Results: A significantly higher TyG index was observed in AF patients (standardized mean difference [SMD]: 0.78; 95% CI: 0.43- 1.13; p<0.001). The TyG index was associated with the risk of AF in both continuous analysis (odds ratio [OR]: 1.80; 95% CI: 1.50-2.17; p<0.001) and category analysis (odds ratio [OR]: 1.98; 95% CI: 1.35-2.91]; p<0.001). Exposure-effect analysis confirmed a linear positive relationship between the TyG index and the risk of AF (plinearity = 0.006).Conclusions: The TyG index is associated with an increased risk of AF, including pure AF, post-operative AF and AF recurrence after ablation. Further studies are needed to confirm the causal relationship between the TyG index and AF.","PeriodicalId":8486,"journal":{"name":"Asia Pacific journal of clinical nutrition","volume":"34 4","pages":"502-515"},"PeriodicalIF":1.5000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310430/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asia Pacific journal of clinical nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.6133/apjcn.202508_34(4).0002","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}

引用次数: 0

Abstract

Background and objectives: Previous studies have demonstrated that insulin resistance (IR) is associated with atrial fibrillation (AF). As a reliable indicator of IR, the triglyceride glucose (TyG) index has been extensively studied in relation to AF. We aimed to investigate the relationship between the TyG index and AF through a systematic review and meta-analysis.

Methods and study design: We systematically searched studies published up to August 2024 in online databases including PubMed, Embase, Web of Science, Wan-fang, and the China National Knowledge Internet database. Seventeen studies involving 57,213 patients were included in the analysis. A random-effects model and exposure-effect analysis were used to calculate the pooled effect estimate and compute the linear trend.

Results: A significantly higher TyG index was observed in AF patients (standardized mean difference [SMD]: 0.78; 95% CI: 0.43- 1.13; p<0.001). The TyG index was associated with the risk of AF in both continuous analysis (odds ratio [OR]: 1.80; 95% CI: 1.50-2.17; p<0.001) and category analysis (odds ratio [OR]: 1.98; 95% CI: 1.35-2.91]; p<0.001). Exposure-effect analysis confirmed a linear positive relationship between the TyG index and the risk of AF (plinearity = 0.006).

Conclusions: The TyG index is associated with an increased risk of AF, including pure AF, post-operative AF and AF recurrence after ablation. Further studies are needed to confirm the causal relationship between the TyG index and AF.

查看原文本刊更多论文

甘油三酯葡萄糖指数与房颤的关系：一项系统综述和荟萃分析。

背景和目的：以往的研究表明胰岛素抵抗（IR）与心房颤动（AF）相关。作为IR的可靠指标，甘油三酯葡萄糖（TyG）指数与AF的关系已被广泛研究。我们旨在通过系统综述和荟萃分析来探讨TyG指数与AF之间的关系。方法和研究设计：系统检索PubMed、Embase、Web of Science、万方、中国国家知识互联网数据库中截止到2024年8月发表的研究。17项研究涉及57,213例患者纳入分析。采用随机效应模型和暴露-效应分析计算合并效应估计值和线性趋势。结果：房颤患者TyG指数明显升高(标准化平均差[SMD]: 0.78；95% ci: 0.43- 1.13；结论：TyG指数与房颤风险增加相关，包括单纯房颤、术后房颤和房颤消融后复发。TyG指数与房颤之间的因果关系有待进一步研究证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Asia Pacific journal of clinical nutrition 医学-营养学

CiteScore

2.50

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The aims of the Asia Pacific Journal of Clinical Nutrition (APJCN) are to publish high quality clinical nutrition relevant research findings which can build the capacity of clinical nutritionists in the region and enhance the practice of human nutrition and related disciplines for health promotion and disease prevention. APJCN will publish original research reports, reviews, short communications and case reports. News, book reviews and other items will also be included. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by at least two anonymous reviewers and the Editor. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as material cannot be returned. Final acceptance or rejection rests with the Editorial Board