Cognitive flexibility decline and right hemisphere's EEG alpha-band functional connectivity reorganization following repetitive indirect brain impacts in parachuters

IF 3.7 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2025-07-28 DOI:10.1016/j.brainresbull.2025.111485

Zhenghao Fu , Kai Hu , Shukai Wu , Shuochen Wang , Haoran Zhang , Huanhuan Li , Hang Xie , Yukang Gong , Guozheng Xu , Jian Song

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Abstract

The current study sought to investigate the relationship between cognitive flexibility and repetitive indirect brain impacts (RIBI) and to unravel the potential electrophysiological mechanism based on functional connectivity analysis. Forty-two male parachuters exposed to RIBI and 40 matched healthy controls (HC) were enrolled. Participants in the RIBI group had completed at least 40 actual jumps (46–106 times) and no less than 1000 simulated platform jumps (1000–4500 times). The RIBI group exhibited a significant increase in whole brain average time-frequency power within the alpha band, and a lower behavioral accuracy rate than the HC group. Spearman correlation revealed that the alpha band time-frequency power was negatively correlated with behavioral accuracy rates for both the repeat (r = -0.307, p = 0.048) and switch (r = -0.347, p = 0.024) conditions in the RIBI group. The RIBI group exhibited decreased alpha coherence (Coh) values predominantly noted between parietal and occipital regions in the right hemisphere, which indicate visual attention deficits in cognitive flexibility processing. Significantly increased alpha Coh values between frontal and parietal regions in the RIBI group, suggesting a compensatory brain response to cognitive flexibility impairment. Overall, this study provides robust evidence that the cumulative effects of RIBI can lead to a decline in cognitive flexibility. Additionally, enhanced frontoparietal and reduced parieto-occipital alpha functional connectivity in the right hemisphere reflects a unique adaptive reorganization of brain activity patterns following RIBI-induced cognitive flexibility impairment.

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重复间接脑冲击后认知灵活性下降和右半球脑电图α带功能连通性重组

本研究旨在探讨认知灵活性与重复性间接脑冲击（RIBI）之间的关系，并在功能连接分析的基础上揭示其潜在的电生理机制。42名暴露于RIBI的男性伞兵和40名匹配的健康对照（HC）被招募。RIBI组的参与者至少完成了40次实际跳跃（46-106次）和不少于1000次模拟平台跳跃（1000 - 4500次）。RIBI组在α波段内的全脑平均时频功率显著增加，行为正确率低于HC组。Spearman相关分析显示，RIBI组的重复（r = -0.307,p = 0.048）和切换（r = -0.347,p = 0.024）的α波段时频功率与行为正确率均呈负相关。RIBI组表现出主要在右半球顶叶和枕叶区域之间的α相干性（Coh）值下降，这表明在认知灵活性加工中存在视觉注意缺陷。RIBI组前额和顶叶区域之间的α - Coh值显著增加，表明大脑对认知灵活性损伤有代偿性反应。总的来说，这项研究提供了强有力的证据，证明RIBI的累积效应会导致认知灵活性的下降。此外，右半球额顶叶功能增强和顶叶-枕叶α功能连接减少反映了ribi诱导的认知灵活性损伤后大脑活动模式的独特适应性重组。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.