Yanan Wu,Yuqing Yang,Rui Wang,Haifeng Yang,Xinling Liu
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引用次数: 0
Abstract
Surface-enhanced Raman scattering (SERS), despite its high sensitivity in molecular fingerprint detection, typically lacks chiral specificity. Chiral metal nanoclusters (CMNCs) with sub-3 nm cores hold promise for chiral molecular sensing, yet their application in SERS-based chiral recognition remains largely unexplored. In this study, two-dimensional self-assembly of Au nanoparticles (NPs, 30 ∼ 50 nm) functionalized with D- or L-penicillamine (Pen) stabilized sub-3 nm Au nanoclusters (NCs) were constructed as SERS-active substrates. On these substrates, distinct SERS signals were observed for L- versus D-phenylalanine (Phe) enantiomers, with a signal intensity difference of approximately 5-fold at a low concentration of 10-6 mol/L, suggesting a good enantiomeric discrimination effect and detection sensitivity. Similar chiral discrimination phenomena were also found by using propranolol enantiomers or chiral Cu NCs. These findings demonstrate the significant potential of the integration of CMNCs into plasmonic SERS substrates for developing sensitive chiral sensing strategies based on nonchiral vibrational Raman spectroscopy and advancing the fundamental studies of metal nanocluster-molecule chiral interactions.
期刊介绍:
Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.