Multiscale Synergistic SERS Chiral Detection: Gold Nanoclusters-Mediated Enantioselective Molecular Discrimination on the Self-Assembly of Gold Nanoparticles.

IF 6.7 1区 化学 Q1 CHEMISTRY, ANALYTICAL
Yanan Wu,Yuqing Yang,Rui Wang,Haifeng Yang,Xinling Liu
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引用次数: 0

Abstract

Surface-enhanced Raman scattering (SERS), despite its high sensitivity in molecular fingerprint detection, typically lacks chiral specificity. Chiral metal nanoclusters (CMNCs) with sub-3 nm cores hold promise for chiral molecular sensing, yet their application in SERS-based chiral recognition remains largely unexplored. In this study, two-dimensional self-assembly of Au nanoparticles (NPs, 30 ∼ 50 nm) functionalized with D- or L-penicillamine (Pen) stabilized sub-3 nm Au nanoclusters (NCs) were constructed as SERS-active substrates. On these substrates, distinct SERS signals were observed for L- versus D-phenylalanine (Phe) enantiomers, with a signal intensity difference of approximately 5-fold at a low concentration of 10-6 mol/L, suggesting a good enantiomeric discrimination effect and detection sensitivity. Similar chiral discrimination phenomena were also found by using propranolol enantiomers or chiral Cu NCs. These findings demonstrate the significant potential of the integration of CMNCs into plasmonic SERS substrates for developing sensitive chiral sensing strategies based on nonchiral vibrational Raman spectroscopy and advancing the fundamental studies of metal nanocluster-molecule chiral interactions.
多尺度协同SERS手性检测:金纳米团簇介导的金纳米粒子自组装对映选择性分子识别。
表面增强拉曼散射(SERS)虽然在分子指纹检测中具有很高的灵敏度,但通常缺乏手性特异性。具有亚3nm核的手性金属纳米团簇(cnc)有望用于手性分子传感,但其在基于sers的手性识别中的应用仍未得到充分探索。在这项研究中,用D-或l -青霉胺(Pen)稳定的亚3纳米金纳米团簇(NCs)构建了二维自组装的金纳米粒子(NPs, 30 ~ 50 nm)作为sers活性底物。在这些底物上,L-和d -苯丙氨酸(Phe)对映体的SERS信号明显,在10-6 mol/L的低浓度下,信号强度相差约5倍,表明它们具有良好的对映体识别效果和检测灵敏度。心得安对映体或手性铜纳米化合物也发现了类似的手性鉴别现象。这些发现表明,将纳米碳纳米管集成到等离子体SERS衬底中,对于开发基于非手性振动拉曼光谱的灵敏手性传感策略以及推进金属纳米簇-分子手性相互作用的基础研究具有重要的潜力。
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来源期刊
Analytical Chemistry
Analytical Chemistry 化学-分析化学
CiteScore
12.10
自引率
12.20%
发文量
1949
审稿时长
1.4 months
期刊介绍: Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.
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