Escherichia coli with a 57-codon genetic code

IF 45.8 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-07-31 DOI:10.1126/science.ady4368

Wesley E. Robertson, Fabian B. H. Rehm, Martin Spinck, Raffael L. Schumann, Rongzhen Tian, Wei Liu, Yangqi Gu, Askar A. Kleefeldt, Cicely F. Day, Kim C. Liu, Yonka Christova, Jérôme F. Zürcher, Franz L. Böge, Jakob Birnbaum, Linda van Bijsterveldt, Jason W. Chin

引用次数: 0

Abstract

The near-universal genetic code uses 64 codons to encode the 20 canonical amino acids and protein synthesis. Here, we designed and generated Escherichia coli with a 4-megabase synthetic genome in which we replaced known occurrences of six sense codons and a stop codon with synonymous codons. The resulting organism, Syn57, uses 55 codons to encode the 20 canonical amino acids.

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有57个密码子的大肠杆菌

这种近乎普遍的遗传密码使用64个密码子编码20种典型氨基酸和蛋白质合成。在这里，我们设计并生成了一个4 Mb的大肠杆菌合成基因组，我们用同义密码子替换了已知的6个意义密码子和一个停止密码子。合成的生物体Syn57使用55个密码子编码20个典型氨基酸。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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