Large Cell Neuroendocrine Carcinoma of the Uterine Cervix With a Biphasic Synaptophysin Staining Pattern and Followed Vaginal Intraepithelial Recurrence: A Case Report

IF 1.1 4区医学 Q4 CELL BIOLOGY

Cytopathology Pub Date : 2025-07-25 DOI:10.1111/cyt.70012

Shinji Toyoda, Kohei Morita, Fuminori Ito, Emiko Niiro, Makiko Taniguchi, Toshiyuki Sado

引用次数: 0

Abstract

This case highlights the importance of early, aggressive surgery for large cell neuroendocrine carcinoma and continuous cytological monitoring in detecting recurrence at the early intraepithelial stage. The pagetoid spread pattern with a biphasic synaptophysin staining differentiated LCNEC from CIN3 and AIS.

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宫颈大细胞神经内分泌癌伴双期突触素染色伴阴道上皮内复发1例报告。

本病例强调了对大细胞神经内分泌癌进行早期积极手术和持续细胞学监测以发现早期上皮内复发的重要性。双相突触素染色的页状扩散模式将LCNEC与CIN3和AIS区分开来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytopathology 生物-病理学

CiteScore

2.30

自引率

15.40%

发文量

107

审稿时长

6-12 weeks

期刊介绍： The aim of Cytopathology is to publish articles relating to those aspects of cytology which will increase our knowledge and understanding of the aetiology, diagnosis and management of human disease. It contains original articles and critical reviews on all aspects of clinical cytology in its broadest sense, including: gynaecological and non-gynaecological cytology; fine needle aspiration and screening strategy. Cytopathology welcomes papers and articles on: ultrastructural, histochemical and immunocytochemical studies of the cell; quantitative cytology and DNA hybridization as applied to cytological material.