Construction of a Scanning Ion-Conductance Microscope for Tip-Enhanced Raman Spectroscopy.

IF 6.7 1区化学 Q1 CHEMISTRY, ANALYTICAL

Analytical Chemistry Pub Date : 2025-07-24 DOI:10.1021/acs.analchem.5c02986

Xing He,Leonardo Scarabelli,Naihao Chiang

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引用次数: 0

Abstract

Tip-enhanced Raman spectroscopy (TERS) has been developed by using atomic force microscopy and scanning tunneling microscopy since its birth in the early 2000s. Because, in principle, any scanning probe microscopy (SPM) can be combined with TERS, there is an increasing interest in extending TERS to other SPMs, especially the liquid-phase ones, targeting applications in biological or catalytic systems. We present the design, construction, and characterization of a laser-coupled scanning ion-conductance microscope (SICM) integrated with TERS for near-field spectroscopy under liquid environments. Key design elements include a full sample-scanning SICM, optics for TERS, and noise-isolating methods. The SICM-TERS system demonstrates direct-current and alternating-current SICM imaging modes on polydimethylsiloxane (PDMS) structures. Furthermore, the TERS capability was tested using silica-nanosphere-grafted PDMS. This work illustrates the feasibility and performance of SICM-TERS as a versatile tool for label-free nanoscale spectroscopy, opening new possibilities for real-time, in situ analysis of soft matter, electrochemical, and biological systems.

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尖端增强拉曼光谱扫描离子电导显微镜的构建。

自21世纪初诞生以来，利用原子力显微镜和扫描隧道显微镜发展了尖端增强拉曼光谱（TERS）。因为，原则上，任何扫描探针显微镜（SPM）都可以与扫描探针显微镜（TERS）相结合，因此将扫描探针显微镜（TERS）扩展到其他扫描探针显微镜，特别是液相扫描探针显微镜，以生物或催化系统为目标应用的兴趣越来越大。我们介绍了一种集成了激光耦合扫描离子电导显微镜（SICM）的液体环境下近场光谱的设计、构建和表征。关键设计元素包括一个完整的样品扫描SICM，光学的TERS，和噪声隔离方法。SICM- ters系统在聚二甲基硅氧烷（PDMS）结构上展示了直流和交流SICM成像模式。此外，使用硅纳米球接枝的PDMS测试了TERS的性能。这项工作说明了SICM-TERS作为无标签纳米尺度光谱的多功能工具的可行性和性能，为软物质、电化学和生物系统的实时、原位分析开辟了新的可能性。

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来源期刊

Analytical Chemistry 化学-分析化学

CiteScore

12.10

自引率

12.20%

发文量

1949

审稿时长

1.4 months

期刊介绍： Analytical Chemistry, a peer-reviewed research journal, focuses on disseminating new and original knowledge across all branches of analytical chemistry. Fundamental articles may explore general principles of chemical measurement science and need not directly address existing or potential analytical methodology. They can be entirely theoretical or report experimental results. Contributions may cover various phases of analytical operations, including sampling, bioanalysis, electrochemistry, mass spectrometry, microscale and nanoscale systems, environmental analysis, separations, spectroscopy, chemical reactions and selectivity, instrumentation, imaging, surface analysis, and data processing. Papers discussing known analytical methods should present a significant, original application of the method, a notable improvement, or results on an important analyte.