Micro/nanoplastic-driven cardiovascular senescence and multi-target intervention by traditional Chinese medicine

IF 12.4 1区医学 Q1 CELL BIOLOGY

Ageing Research Reviews Pub Date : 2025-07-21 DOI:10.1016/j.arr.2025.102841

Yuan Liu , Yuetong Li , Yue Yin , Lu Yu , Heng Ma

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引用次数: 0

Abstract

Micro/nanoplastics (MNPs), pervasive environmental pollutants, accumulate in cardiovascular tissues and drive premature aging through multiscale pathophysiological cascades. This review synthesizes evidence establishing environmental phenotypic aging as a novel mechanistic link between MNP exposure and cardiovascular senescence. MNPs induce mitochondrial damage involving cristae disruption and mtDNA leakage activating cGAS-STING, epigenetic reprogramming encompassing METTL3-mediated m6A hypermethylation and SIRT1/3 suppression, telomere attrition, and NLRP3 inflammasome-dependent inflammaging. It is crucial to note that traditional Chinese medicine (TCM) has been identified as an effective countermeasure. The multi-compound therapeutics of TCM simultaneously target oxidative stress, inflammatory fibrosis, and cell death pathways, thereby restoring cardiovascular homeostasis. By combining environmental toxicology and geroprotection research, this work establishes TCM's holistic approach as a paradigm-shifting intervention against the cardiovascular aging caused by plastic pollution, providing practical strategies to address a mounting public health crisis.

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微/纳米塑料驱动的心血管衰老及中药多靶点干预。

微/纳米塑料（MNPs）是普遍存在的环境污染物，在心血管组织中积累，并通过多尺度病理生理级联反应驱动过早衰老。这篇综述综合了环境表型衰老作为MNP暴露和心血管衰老之间的一种新的机制联系的证据。MNPs诱导线粒体损伤（嵴破坏，mtDNA泄漏激活cGAS-STING），表观遗传重编程（mettl3介导的m6A超甲基化，SIRT1/3抑制），端粒磨损和NLRP3炎症小体依赖性炎症。必须指出的是，中医已被确定为有效的对策。中医药多重复合疗法同时针对氧化应激、炎症纤维化和细胞死亡途径，从而恢复心血管稳态。通过结合环境毒理学和老年保护研究，本研究建立了中医整体方法作为范式转换干预塑料污染引起的心血管衰老，为解决日益严重的公共卫生危机提供实用策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.