Potential effects of Asian-adapted Mediterranean diet in depression and anxiety among women with metabolic dysfunction-associated steatotic liver disease: a secondary analysis.
Alicia Salamanca-Sanabria, Yu Chung Chooi, Evelyn Xiu Ling Loo, Xianning Lai, Vera Sergeyevna Brok Volchanskaya, Yap Seng Chong, Johan Gunnar Eriksson
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引用次数: 0
Abstract
Background: Common Mental Disorders (CMDs) such as anxiety and depression have been associated with metabolic dysfunction-Associated steatotic Liver Disease (MASLD). The Mediterranean Diet (MD) has been shown to improve metabolic health and reduce CMDs. We previously reported that a calorie-restricted MD adapted to the Asian food culture has beneficial effects on body composition, liver fat, and cardiometabolic markers in Chinese Singaporean women with MASLD.
Objective: This secondary analysis examines the effects of an Asian-adapted MD on the symptoms of anxiety and depression in the same population.
Methods: In a double-blind, parallel-design, randomized controlled trial, 84 Chinese- Singaporean females with MASLD were randomly assigned to 1 of the 3 groups for 12 weeks: adapted Asian MD with C15:0 supplementation (n = 29), diet without C15:0 supplementation (n = 26), or control (habitual diet and no C15:0 supplementation, n = 29). Depression and anxiety symptoms were assessed using the Beck Inventory Questionnaire (BDI-II) and the State-Trait Anxiety Inventory (STAI).
Results: Paired t-tests showed a statistically significant reduction in anxiety and depression symptoms within the groups. Particularly, the Diet+C15 group showed a significant decrease in trait anxiety scores (M = 38.62, SE = 1.84 to M = 34.10, SE = 1.73), t (28) = 3.73, p < 0.001, with a medium-to-large effect size (d = 0.69) Jacobson and Truax's reliable change criteria showed clinically reliable improvements in anxiety and depression postintervention.
Conclusion: The Asian-adapted MD shows potential benefits for reducing anxiety and depression symptoms, particularly trait anxiety in women with MASLD. However, given the complexity of CMD, findings should be interpreted cautiously. Future research with larger sample sizes is needed to confirm these effects and explore underlying mechanisms.
期刊介绍：
No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health.
Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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