Gut microbiota-derived SCFAs and MetS-related nephropathy.

IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS
Frontiers in Nutrition Pub Date : 2025-07-08 eCollection Date: 2025-01-01 DOI:10.3389/fnut.2025.1561271
Xiaofang Tian, Li Sun, Shengjie Guo, Liying Yuan, Tang Zhang, Chengqian Huang, Tingting He, Qianfeng Jiang, Yizhou Zeng
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Abstract

Metabolic syndrome (MetS) is a group of complex disorders characterized by abnormalities in the metabolism of proteins, fats, carbohydrates, and other substances in the human body. The kidney plays a vital role in these metabolic processes. Similarly, metabolic disorders can lead to renal damage, which can affect both its structure and function. The human intestinal tract possesses an abundant and diverse gut microbial community that significantly influences the physiology and pathology of the host. Growing evidence suggests that gut microbiota-derived metabolites exhibit multiple effects (anti-inflammatory, antioxidant, and improvement of lipid metabolism) in MetS. Particularly, considerable research has suggested that gut microbiota-derived short-chain fatty acids (SCFAs) have an intimate relationship with MetS-related nephropathy. The functions of SCFAs are involved in modulating energy metabolism, regulating immune and inflammatory responses, and inhibiting oxidative stress and mitochondrial damage, which are mainly through the activation of transmembrane G protein-coupled receptors (GPRs) and the inhibition of Histone deacetylase activity (HDAC). Regarding MetS-related nephropathy, therapeutic studies of SCFAs have been conducted in both clinical investigations and animal experiments. However, the role of SCFAs in kidney damage caused by various metabolic disorders has not been fully elucidated. The aim of this article is to review the role of SCFAs in MetS-related nephropathy, which will provide a prospective therapy strategy for MetS-related nephropathy.

肠道微生物源性SCFAs和met相关肾病。
代谢综合征(MetS)是一组以人体内蛋白质、脂肪、碳水化合物和其他物质代谢异常为特征的复杂疾病。肾脏在这些代谢过程中起着至关重要的作用。同样,代谢紊乱可导致肾脏损害,从而影响其结构和功能。人类肠道拥有丰富多样的肠道微生物群落,对宿主的生理和病理有重要影响。越来越多的证据表明,肠道微生物衍生的代谢物在MetS中表现出多种作用(抗炎、抗氧化和改善脂质代谢)。特别是,大量研究表明,肠道菌群衍生的短链脂肪酸(SCFAs)与met相关性肾病有密切关系。SCFAs主要通过激活跨膜G蛋白偶联受体(GPRs)和抑制组蛋白去乙酰化酶活性(HDAC),参与调节能量代谢、调节免疫和炎症反应、抑制氧化应激和线粒体损伤等功能。对于mets相关性肾病,SCFAs的治疗研究已经在临床研究和动物实验中进行。然而,SCFAs在各种代谢紊乱引起的肾损害中的作用尚未完全阐明。本文的目的是回顾SCFAs在met相关性肾病中的作用,为met相关性肾病的前瞻性治疗策略提供参考。
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来源期刊
Frontiers in Nutrition
Frontiers in Nutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.20
自引率
8.00%
发文量
2891
审稿时长
12 weeks
期刊介绍: No subject pertains more to human life than nutrition. The aim of Frontiers in Nutrition is to integrate major scientific disciplines in this vast field in order to address the most relevant and pertinent questions and developments. Our ambition is to create an integrated podium based on original research, clinical trials, and contemporary reviews to build a reputable knowledge forum in the domains of human health, dietary behaviors, agronomy & 21st century food science. Through the recognized open-access Frontiers platform we welcome manuscripts to our dedicated sections relating to different areas in the field of nutrition with a focus on human health. Specialty sections in Frontiers in Nutrition include, for example, Clinical Nutrition, Nutrition & Sustainable Diets, Nutrition and Food Science Technology, Nutrition Methodology, Sport & Exercise Nutrition, Food Chemistry, and Nutritional Immunology. Based on the publication of rigorous scientific research, we thrive to achieve a visible impact on the global nutrition agenda addressing the grand challenges of our time, including obesity, malnutrition, hunger, food waste, sustainability and consumer health.
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