Paraneoplastic Erythroderma: A Rare, but Important Cause of Mixed Pattern Dermatitis.

IF 1.1 4区 医学 Q3 DERMATOLOGY
Gabriela Fonseca, Hana Ahmed, Lauren Graham, Carly Elston
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Abstract

In dermatopathology, mixed inflammatory patterns, such as mixed spongiotic and interface dermatitis (SID) are not well-characterized and can present a diagnostic challenge. This pattern can be seen in drug eruptions, viral exanthems, and syphilis infection. We present two cases of paraneoplastic erythroderma characterized by a mixed pattern SID. The patients underwent an extensive workup and were found to have positive antinuclear antibodies (ANA) in the absence of symptoms diagnostic of connective tissue disease. Eventually, the patients were both diagnosed with malignancies (systemic marginal zone lymphoma and breast cancer). It is important for dermatopathologists to consider paraneoplastic dermatitis in the differential diagnosis of mixed pattern SID, particularly in the clinical setting of erythroderma, as these findings can be the presenting sign of underlying malignancy. Additionally, if antinuclear antibodies are detected in the absence of classic clinical signs of connective tissue disease, a thorough workup should be conducted to exclude malignancy.

副肿瘤性红皮病:一种罕见但重要的混合型皮炎病因。
在皮肤病理学中,混合性炎症模式,如混合性海绵状和界面皮炎(SID)没有很好的特征,可能会给诊断带来挑战。这种模式可以在药疹、病毒疹和梅毒感染中看到。我们报告了两例以混合型SID为特征的副肿瘤性红皮病。患者接受了广泛的检查,在没有结缔组织病诊断症状的情况下,发现抗核抗体(ANA)阳性。最终,两名患者均被诊断为恶性肿瘤(全身边缘区淋巴瘤和乳腺癌)。对于皮肤科医生来说,在鉴别诊断混合型SID时考虑副肿瘤性皮炎是很重要的,特别是在红皮病的临床背景下,因为这些发现可能是潜在恶性肿瘤的表现。此外,如果在没有结缔组织病的典型临床体征的情况下检测到抗核抗体,则应进行彻底的检查以排除恶性肿瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
174
审稿时长
3-8 weeks
期刊介绍: Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.
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