Gabriela Fonseca, Hana Ahmed, Lauren Graham, Carly Elston
{"title":"Paraneoplastic Erythroderma: A Rare, but Important Cause of Mixed Pattern Dermatitis.","authors":"Gabriela Fonseca, Hana Ahmed, Lauren Graham, Carly Elston","doi":"10.1111/cup.14851","DOIUrl":null,"url":null,"abstract":"<p><p>In dermatopathology, mixed inflammatory patterns, such as mixed spongiotic and interface dermatitis (SID) are not well-characterized and can present a diagnostic challenge. This pattern can be seen in drug eruptions, viral exanthems, and syphilis infection. We present two cases of paraneoplastic erythroderma characterized by a mixed pattern SID. The patients underwent an extensive workup and were found to have positive antinuclear antibodies (ANA) in the absence of symptoms diagnostic of connective tissue disease. Eventually, the patients were both diagnosed with malignancies (systemic marginal zone lymphoma and breast cancer). It is important for dermatopathologists to consider paraneoplastic dermatitis in the differential diagnosis of mixed pattern SID, particularly in the clinical setting of erythroderma, as these findings can be the presenting sign of underlying malignancy. Additionally, if antinuclear antibodies are detected in the absence of classic clinical signs of connective tissue disease, a thorough workup should be conducted to exclude malignancy.</p>","PeriodicalId":15407,"journal":{"name":"Journal of Cutaneous Pathology","volume":" ","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Cutaneous Pathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/cup.14851","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DERMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
In dermatopathology, mixed inflammatory patterns, such as mixed spongiotic and interface dermatitis (SID) are not well-characterized and can present a diagnostic challenge. This pattern can be seen in drug eruptions, viral exanthems, and syphilis infection. We present two cases of paraneoplastic erythroderma characterized by a mixed pattern SID. The patients underwent an extensive workup and were found to have positive antinuclear antibodies (ANA) in the absence of symptoms diagnostic of connective tissue disease. Eventually, the patients were both diagnosed with malignancies (systemic marginal zone lymphoma and breast cancer). It is important for dermatopathologists to consider paraneoplastic dermatitis in the differential diagnosis of mixed pattern SID, particularly in the clinical setting of erythroderma, as these findings can be the presenting sign of underlying malignancy. Additionally, if antinuclear antibodies are detected in the absence of classic clinical signs of connective tissue disease, a thorough workup should be conducted to exclude malignancy.
期刊介绍:
Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.