Primary Cutaneous Rosai-Dorfman Disease: A Cyto-Histo Correlate.

IF 1.1 4区 医学 Q4 CELL BIOLOGY
Cytopathology Pub Date : 2025-07-21 DOI:10.1111/cyt.70010
Nimisha Dhankar, Meeta Singh, Raman Sharma, Nita Khurana, Ravi Mehar
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引用次数: 0

Abstract

Primary cutaneous Rosai-Dorfman disease (RDD) is a rare proliferative disorder of histiocytes involving exclusively skin. The diagnosis of cutaneous RDD relies on clinical, histopathological and immunohistochemical findings. Cytological diagnosis can also be made in the presence of diagnostic features like histiocytic proliferation and prominent emperipolesis. We present two rare cases of primary cutaneous RDD: a 20-year-old male and an 8-year-old male, diagnosed on fine-needle aspiration cytology (FNAC). The first case was multicentric with swellings on the nose and arm, while the second patient had a single swelling on the right pinna. FNAC was reported as cutaneous RDD in both cases, which was later confirmed on histopathology and immunohistochemistry.

原发性皮肤Rosai-Dorfman病:细胞组织相关。
原发性皮肤Rosai-Dorfman病(RDD)是一种罕见的组织细胞增殖性疾病,仅累及皮肤。皮肤RDD的诊断依赖于临床、组织病理学和免疫组织化学结果。细胞学诊断也可以在存在诊断特征,如组织细胞增殖和明显的上皮增生。我们报告两例罕见的原发性皮肤RDD病例:一名20岁男性和一名8岁男性,通过细针穿刺细胞学(FNAC)诊断。第一例为多中心性鼻部和上臂肿胀,而第二例患者为右侧耳廓单一肿胀。两例病例均报告FNAC为皮肤RDD,随后经组织病理学和免疫组织化学证实。
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来源期刊
Cytopathology
Cytopathology 生物-病理学
CiteScore
2.30
自引率
15.40%
发文量
107
审稿时长
6-12 weeks
期刊介绍: The aim of Cytopathology is to publish articles relating to those aspects of cytology which will increase our knowledge and understanding of the aetiology, diagnosis and management of human disease. It contains original articles and critical reviews on all aspects of clinical cytology in its broadest sense, including: gynaecological and non-gynaecological cytology; fine needle aspiration and screening strategy. Cytopathology welcomes papers and articles on: ultrastructural, histochemical and immunocytochemical studies of the cell; quantitative cytology and DNA hybridization as applied to cytological material.
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