The Dual Role of Conjugated Linoleic Acid in Obesity and Metabolic Disorders

IF 3.5 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Food Science & Nutrition Pub Date : 2025-07-22 DOI:10.1002/fsn3.70582

Magendran Rajendran, Shanmugasundaram Palani, Thakur Gurjeet Singh, Brian Oliver, Kaml Dua, Vetriselvan Subramaniyan, Kumaran Narayanan

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Abstract

Conjugated Linoleic Acid (cis-9, trans-11, CLA)/(trans-10, cis-12, CLA) has been extensively studied for its role in obesity control and metabolic diseases. This review explores the molecular characteristics of CLA, its metabolic pathways, and its inconsistent effects on lipid metabolism, adipogenesis, energy expenditure, and inflammation. Preclinical and clinical studies suggest that CLA may promote fat oxidation and modulate adipocyte function; however, inconsistent findings highlight dose-dependent outcomes and individual variability in response. The dual nature of CLA, showing both beneficial and adverse effects, raises questions about its long-term safety and efficacy. This review critically examines CLA's molecular role in obesity and metabolic regulation, providing insights into its therapeutic promise and limitations. Future research should focus on personalized approaches to CLA supplementation, considering genetic and lifestyle factors for tailored nutritional guidance.

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共轭亚油酸在肥胖和代谢紊乱中的双重作用

共轭亚油酸（顺式-9，反式-11，CLA）/（反式-10，顺式-12，CLA）在肥胖控制和代谢性疾病中的作用已被广泛研究。本文综述了CLA的分子特征、代谢途径及其对脂质代谢、脂肪生成、能量消耗和炎症的不一致影响。临床前和临床研究表明，CLA可能促进脂肪氧化和调节脂肪细胞功能；然而，不一致的研究结果强调了剂量依赖性结果和反应的个体可变性。CLA的双重性质，既有有利的一面，也有不利的一面，这对其长期的安全性和有效性提出了质疑。本文综述了CLA在肥胖和代谢调节中的分子作用，为其治疗前景和局限性提供了见解。未来的研究应侧重于个性化的CLA补充方法，考虑遗传和生活方式因素，以提供量身定制的营养指导。

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来源期刊

Food Science & Nutrition Agricultural and Biological Sciences-Food Science

CiteScore

7.40

自引率

5.10%

发文量

434

审稿时长

24 weeks

期刊介绍： Food Science & Nutrition is the peer-reviewed journal for rapid dissemination of research in all areas of food science and nutrition. The Journal will consider submissions of quality papers describing the results of fundamental and applied research related to all aspects of human food and nutrition, as well as interdisciplinary research that spans these two fields.