Exploration of Biomarkers of Food Intake in a Caribbean Hispanic Population.

IF 4.2 2区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Molecular Nutrition & Food Research Pub Date : 2025-07-21 DOI:10.1002/mnfr.70158

Laurence D Parnell,Liam E Fouhy,Oladimeji Akinlawon,Chao-Qiang Lai,Frederick Nusetor,José M Ordovás,Kelsey M Mangano,Katherine L Tucker,Sabrina E Noel

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引用次数: 0

Abstract

Valid measures of dietary intake are essential for health and nutrition research, but typical forms- or interview-based measurements are susceptible to random and systematic errors. Although many biomarkers of food intake (BFIs) have been validated, we aimed to explore how food-BFI relationships are affected by genetic and lifestyle factors among Caribbean Hispanic adults. Dietary, clinical, anthropometric, blood metabolomics, and genotype data from 782 Puerto Rican adults were available. Thirty-one BFI-food intake relationships were assessed using linear regression, including covariates based on significant covariate-BFI associations (i.e., age, body weight, physical activity, and sex). We observed 12 known BFI-food pairs that reached statistical significance, of which 11 remained significant after adjustment. Applying genome-wide association tests of blood metabolites to BFI-food pairs, genetic variants rs7078243 and rs62501664 were identified as modifying relationships with 3-methylxanthine-coffee and 3-methylhistidine-poultry, respectively. Eleven validated biomarker-food intake pairs remained statistically significant after adjusting for covariates. Identification of genotype-BFI associations accentuates that the implementation of certain BFIs will depend on common genetic differences.

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加勒比西班牙裔人群食物摄入生物标志物的探索。

膳食摄入量的有效测量对于健康和营养研究至关重要，但典型的表格或基于访谈的测量容易受到随机和系统错误的影响。虽然许多食物摄入（bfi）的生物标志物已经得到验证，但我们的目的是探索加勒比西班牙裔成年人的食物- bfi关系如何受到遗传和生活方式因素的影响。来自782名波多黎各成年人的饮食、临床、人体测量学、血液代谢组学和基因型数据可用。使用线性回归评估31个bfi -食物摄入关系，包括基于显著协变量- bfi关联的协变量（即年龄、体重、体力活动和性别）。我们观察到12个已知的bfi -食物对达到统计学显著性，其中11个调整后仍然显著。利用bfi -食物对血液代谢物的全基因组关联检测，鉴定出rs7078243和rs62501664基因变异分别与3-甲基黄嘌呤-咖啡和3-甲基组氨酸-家禽存在修饰关系。在调整协变量后，11个有效的生物标志物-食物摄入对仍然具有统计学意义。基因型- bfi关联的鉴定强调了某些bfi的实施将取决于共同的遗传差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Nutrition & Food Research 工程技术-食品科技

CiteScore

8.70

自引率

1.90%

发文量

250

审稿时长

1.7 months

期刊介绍： Molecular Nutrition & Food Research is a primary research journal devoted to health, safety and all aspects of molecular nutrition such as nutritional biochemistry, nutrigenomics and metabolomics aiming to link the information arising from related disciplines: Bioactivity: Nutritional and medical effects of food constituents including bioavailability and kinetics. Immunology: Understanding the interactions of food and the immune system. Microbiology: Food spoilage, food pathogens, chemical and physical approaches of fermented foods and novel microbial processes. Chemistry: Isolation and analysis of bioactive food ingredients while considering environmental aspects.