Stimulated cytokine production, attachment, and emotional well-being in dementia spousal caregivers.

IF 3.1 2区心理学 Q1 PSYCHOLOGY

Health Psychology Pub Date : 2025-07-17 DOI:10.1037/hea0001533

Daniel L Argueta, Sarah Roberts, Kelly N Brice, E Lydia Wu-Chung, Vincent D Lai, Jensine Paoletti-Hatcher, Bryan T Denny, Charles Green, Samantha Henry, Luis D Medina, Paul E Schulz, Jennifer Stinson, Cobi Heijnen, Christopher P Fagundes

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引用次数: 0

Abstract

Background: Proinflammatory cytokine production may be related to poor emotional adjustment in dementia spousal caregivers. People who display attachment insecurity may be at increased risk for adverse caregiving experiences and poor psychosocial outcomes.

Objective: This study aimed to understand whether proinflammatory cytokine production was associated with anticipatory grief, caregiver burden, and depressive symptoms and whether those relationships were stronger for caregivers higher on attachment anxiety or avoidance.

Method: A sample of 103 dementia spousal caregivers provided self-report data on demographics, health information, and psychosocial outcomes. We also determined lipopolysaccharide-induced whole-blood interleukin-6, interleukin-1β, tumor necrosis factor-α, and interleukin-10 production and combined these cytokines into a composite score.

Results: Higher cytokine production was associated with increased anticipatory grief and depressive symptoms. Proinflammatory cytokine production was only associated with anticipatory grief, caregiver burden, and depressive symptoms for those high on attachment anxiety or avoidance.

Discussion: Targeting individuals who display a proinflammatory phenotype and report attachment insecurity may be a key first step in preventing poor caregiving adjustment in dementia spousal caregivers. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

查看原文本刊更多论文

受刺激的细胞因子产生，依恋，和痴呆配偶照顾者的情绪健康。

背景：促炎细胞因子的产生可能与痴呆配偶照顾者情绪调节不良有关。表现出依恋不安全感的人可能面临不良照顾经历和不良心理社会结果的风险增加。目的：本研究旨在了解促炎细胞因子的产生是否与预期悲伤、照顾者负担和抑郁症状相关，以及这些关系是否在依恋焦虑或回避程度较高的照顾者中更强。方法：103名痴呆配偶照顾者提供了人口统计学、健康信息和社会心理结果的自我报告数据。我们还测定了脂多糖诱导的全血白细胞介素-6、白细胞介素-1β、肿瘤坏死因子-α和白细胞介素-10的产生，并将这些细胞因子组合成一个综合评分。结果：较高的细胞因子产生与预期悲伤和抑郁症状的增加有关。促炎细胞因子的产生仅与预期悲伤、照顾者负担和依恋焦虑或回避程度高的人的抑郁症状有关。讨论：针对那些表现出促炎表型并报告依恋不安全感的个体，可能是预防痴呆配偶照顾者照顾调整不良的关键第一步。（PsycInfo Database Record (c) 2025 APA，版权所有）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Health Psychology 医学-心理学

CiteScore

4.90

自引率

2.40%

发文量

170

审稿时长

4-8 weeks

期刊介绍： Health Psychology publishes articles on psychological, biobehavioral, social, and environmental factors in physical health and medical illness, and other issues in health psychology.