Sirma Orguc, Ohyoon Kwon, Marusa Naranjo Gonzalez, Emery N Brown
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引用次数: 0
Abstract
Propanidid is an intravenous short-acting sedative-hypnotic anesthetic in the eugenol family that acts as a positive allosteric modulator of the gamma-aminobutyric acid type A (GABAA) receptor. However, its neural circuit mechanisms have not been characterized. We compared the EEG signatures of patients anesthetized with propanidid to those anesthetized with propofol. We characterized the EEG recordings of 13 propanidid- and 13 propofol-mediated general anesthesia cases using spectral and coherence analyses. During propanidid-mediated unconsciousness, we observed a significant increase in the 0-18.5 Hz power and a decrease in the 30.5-40 Hz power compared with the baseline. Compared to the propofol cohort, the suppression in the 23-40 Hz band power was significantly less in the propanidid cohort during unconsciousness. The coherence in the 0-40 Hz range was not significantly different between the two cohorts. The propanidid cohort showed a shorter average offset time (4.8 min) than the propofol cohort (5.9 min), which was not significant. This preliminary investigation showed that the EEG signatures of propanidid-mediated unconsciousness are similar to those of propofol, suggesting a similar GABAergic mechanism of network action. Our work provides a basis to characterize the neural mechanisms of propanidid-mediated sedation and unconsciousness.NEW & NOTEWORTHY Propanidid is a short-acting intravenous anesthetic of the eugenol group that has been safely used in Mexico for over 20 years. Like propofol, it acts via GABAergic mechanisms; however, its effects on neural circuits remain uncharacterized. Therefore, we compared EEG signatures between patients anesthetized with propanidid and propofol. Our work suggests similar neural mechanisms for propanidid and propofol. As with propofol, propanidid's EEG signatures could be used to monitor sedation and unconsciousness.
目的:丙炔醇是丁香酚家族中的一种静脉短效镇静催眠麻醉剂,可作为γ -氨基丁酸a型(G a B a a)受体的正变构调节剂。然而,其神经回路机制尚未明确。我们比较了丙胺麻醉与异丙酚麻醉患者的脑电图特征。方法:对13例丙泊酚和13例丙泊酚全身麻醉患者的脑电图记录进行波谱分析和相干分析。结果:在丙炔醇介导的无意识过程中,我们观察到与基线相比,0-18.5 Hz功率显著增加,30.5-40 Hz功率显著降低。与丙泊酚组相比,丙泊酚组在无意识状态下对23-40 Hz波段功率的抑制明显减少。在0-40 Hz范围内的相干性在两个队列之间没有显着差异。丙泊酚组的平均偏移时间(4.8分钟)比丙泊酚组(5.9分钟)短,但差异不显著。结论:本初步研究表明,丙帕胺介导的无意识脑电特征与异丙酚相似,提示其网络作用的gaba能机制相似。意义:我们的工作为揭示丙炔醇介导的镇静和无意识的神经机制提供了基础。
期刊介绍:
The Journal of Neurophysiology publishes original articles on the function of the nervous system. All levels of function are included, from the membrane and cell to systems and behavior. Experimental approaches include molecular neurobiology, cell culture and slice preparations, membrane physiology, developmental neurobiology, functional neuroanatomy, neurochemistry, neuropharmacology, systems electrophysiology, imaging and mapping techniques, and behavioral analysis. Experimental preparations may be invertebrate or vertebrate species, including humans. Theoretical studies are acceptable if they are tied closely to the interpretation of experimental data and elucidate principles of broad interest.