Bletistrosides M-X, Anti-Alzheimer's Disease Compounds from the Tubers of Bletilla striata.

IF 3.3 2区生物学 Q2 CHEMISTRY, MEDICINAL

Journal of Natural Products Pub Date : 2025-07-15 DOI:10.1021/acs.jnatprod.5c00486

Zhiwei Bian, Xiaoying Liu, Jiaxuan Li, Shian Hu, Yeun-Mun Choo, Zeyu Zhao, Jinfeng Hu, Kangrui Ji, Mark T Hamann, Xin Wang, Xiaojuan Wang

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引用次数: 0

Abstract

Twelve new compounds, bletistrosides M-X (1-12), including five glucosyloxybenzyl 2-isobutylmalates (1-5), along with four neolignan glycosides (6-9), two phenanthrene derivatives (10-11), and one bibenzyl derivative (12), were isolated from the tubers of Bletilla striata (B. striata). The structures and absolute configurations of the undescribed compounds were elucidated on the basis of spectroscopic data analysis, experimental and calculated electronic circular dichroism data, chiroptical analysis, and chemical derivatizations. In silico, compounds 2, 3, and 12 bound well to Aβ_1-42. Compounds 2, 3, and 12 significantly delayed the paralysis phenotype in CL4176 worms compared to controls. Higher nonparalysis rates were observed in these treatment groups (5 μM for compound 2; 25, 50 μM for compounds 2, 3 and 12), suggesting their potential role in anti-Alzheimer's disease.

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白芨块茎抗阿尔茨海默病化合物。

从白芨（B. striata）块茎中分离到12个新化合物：白芨苷M-X(1-12)，包括5个糖基氧氧苄基2-异丁基苹果酸酯（1-5）、4个新木质素苷（6-9）、2个菲衍生物（10-11）和1个联苯衍生物（12）。根据光谱数据分析、实验和计算的电子圆二色性数据、热学分析和化学衍生分析，阐明了所描述化合物的结构和绝对构型。在硅中，化合物2、3和12与a - β1-42结合良好。与对照组相比，化合物2、3和12显著延缓了CL4176蠕虫的麻痹表型。这些治疗组观察到更高的非麻痹率(化合物2 5 μM；化合物2、3和12的活性为25、50 μM)，表明它们具有抗阿尔茨海默病的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Natural Products 生物-药学

CiteScore

9.10

自引率

5.90%

发文量

294

审稿时长

2.3 months

期刊介绍： The Journal of Natural Products invites and publishes papers that make substantial and scholarly contributions to the area of natural products research. Contributions may relate to the chemistry and/or biochemistry of naturally occurring compounds or the biology of living systems from which they are obtained. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin. When new compounds are reported, manuscripts describing their biological activity are much preferred. Specifically, there may be articles that describe secondary metabolites of microorganisms, including antibiotics and mycotoxins; physiologically active compounds from terrestrial and marine plants and animals; biochemical studies, including biosynthesis and microbiological transformations; fermentation and plant tissue culture; the isolation, structure elucidation, and chemical synthesis of novel compounds from nature; and the pharmacology of compounds of natural origin.