Multi-Omics Analysis Reveals the Selenium-Regulatory Metabolism in Rare Yeast Kazachstania unispora KU2

IF 6.9 Q1 FOOD SCIENCE & TECHNOLOGY

Food frontiers Pub Date : 2025-06-02 DOI:10.1002/fft2.70014

Furong Wang, Jiadi Zhang, Yilei Xiao, Zeyu Hu, Xian Wang, Yuqi Gao, Kewei Feng, Yahong Yuan, Tianli Yue

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Abstract

Selenium (Se)-enriched yeast is the best Se source to address Se deficiency–related health issues. Kazachstania unispora (K. unispora) is a rare yeast that effectively bioaccumulates organic Se. However, the Se enrichment mechanism of K. unispora remains poorly characterized. This study explored the characteristic differences between Se-enriched K. unispora KU2 and non-enriched counterpart via integrated genomics, transcriptomics, and metabolomics analysis. A total of 138 metabolites and 1561 genes exhibited significant alternations during Se enrichment. Joint analysis revealed unique Se-regulatory pathways, predominately arginine biosynthesis, the TCA cycle, glutathione metabolism, and selenocompound metabolism. Among them, seven differentially expressed genes, including glnA, E1.2.1.88, DLD, acnA, GPT, metH, and CTH, were identified as key Se-regulatory genes in K. unispora KU2. These findings provide useful knowledge for targeting Se levels in K. unispora and new insights into commercial application of K. unispora as a probiotic to promote human health.

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稀有酵母Kazachstania unispora KU2硒调控代谢的多组学分析

富硒酵母是解决硒缺乏相关健康问题的最佳硒来源。Kazachstania unispora （K. unispora）是一种罕见的能有效生物积累有机硒的酵母。然而，对紫杉的硒富集机制尚不清楚。本研究通过整合基因组学、转录组学和代谢组学分析，探讨了富硒K. unispora KU2与非富硒K. KU2的特征差异。在硒富集过程中，共有138个代谢物和1561个基因发生了显著变化。联合分析揭示了独特的硒调节途径，主要是精氨酸生物合成、TCA循环、谷胱甘肽代谢和硒化合物代谢。其中，glnA、E1.2.1.88、DLD、acnA、GPT、metH、CTH等7个差异表达基因被鉴定为K. unispora KU2的关键硒调控基因。这些发现为确定紫杉菌硒水平提供了有用的知识，并为紫杉菌作为益生菌的商业应用提供了新的见解。

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