Central Blood Pressure and Augmentation Index in Older Adults With Intellectual Disabilities.

IF 2.1 2区医学 Q1 EDUCATION, SPECIAL

Journal of Intellectual Disability Research Pub Date : 2025-07-14 DOI:10.1111/jir.70002

T I M Hilgenkamp, A Oppewal, M N Bohmer, A Paul, C Ryan, E Burke, M McCarron, P McCallion, D A M Maes-Festen, F O'Brien

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引用次数: 0

Abstract

Background: Older adults with intellectual disabilities are at a higher cardiovascular risk than their peers in the general population. Investigating central blood pressure and augmentation index is necessary to better understand the risk of cardiovascular disease, to better identify those individuals at risk and to potentially change pharmacological treatment regimens. We therefore aim to investigate central blood pressure and augmentation index in two large cohorts (total N = 237) of older adults with intellectual disabilities, across different age ranges and sexes. Additionally, we will explore the cross-sectional relationships of central blood pressure and augmentation index with other cardiovascular risk factors and the presence of cardiovascular disease across a broad age range.

Method: Collected data of two cohorts of older adults with intellectual disabilities were included: n = 121 individuals with intellectual disabilities of ≥ 60 years from the Healthy Ageing and Intellectual Disabilities (HA-ID) study, and n = 115 individuals with intellectual disabilities ≥ 40 years from The Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA) study. The Mobil-O-Graph was used to measure central blood pressure and augmentation index. The distribution of haemodynamic measures across different sex and age groups was reported, and bivariate correlations were calculated to explore associations between haemodynamic measures, cardiovascular risk factors and history of CVD.

Results: Mean brachial pressures for the HA-ID cohort (mean age 71 ± 6 years) was 133/81 mmHg. The slightly younger IDS-TILDA cohort (mean age 60 ± 9 years) had a median brachial blood pressure of 127/81. Mean central SBP (cSBP) in the older HA-ID cohort was 122 mmHg versus 120 mmHg in the younger IDS-TILDA cohort, with a central DBP (cDBP) of 82 mmHg in both cohorts, and a central pulse pressure (cPP, cSBP-cDBP) of 40 mmHg for the HA-ID cohort and 38 mmHg for the IDS-TILDA cohort.

Conclusions: Females with intellectual disabilities had higher central blood pressures, augmentation pressure and augmentation index than males, and females showed an age-related increase in central blood pressures.

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老年智力障碍患者的中心血压和增高指数。

背景：患有智力障碍的老年人患心血管疾病的风险高于普通人群中的同龄人。调查中心血压和升高指数对于更好地了解心血管疾病的风险，更好地识别那些有风险的个体，并可能改变药物治疗方案是必要的。因此，我们的目的是在两个大型队列（总N = 237）中调查不同年龄和性别的智力残疾老年人的中心血压和增强指数。此外，我们将在广泛的年龄范围内探讨中心血压和增强指数与其他心血管危险因素和心血管疾病存在的横断面关系。方法：收集两组智力残疾老年人的数据：n = 121例来自健康老龄化和智力残疾（HA-ID）研究的≥60岁的智力残疾个体，n = 115例来自爱尔兰老龄化纵向研究的智力残疾补充（IDS-TILDA）研究的≥40岁的智力残疾个体。mobilo - graph测量中心血压和升高指数。报告了血流动力学指标在不同性别和年龄组的分布，并计算了双变量相关性，以探讨血流动力学指标、心血管危险因素和CVD病史之间的关联。结果：HA-ID队列的平均臂压（平均年龄71±6岁）为133/81 mmHg。稍年轻的IDS-TILDA队列（平均年龄60±9岁）的中位肱血压为127/81。老年HA-ID队列的平均中央收缩压（cSBP）为122 mmHg，而年轻IDS-TILDA队列为120 mmHg，两个队列的中心舒张压（cDBP）均为82 mmHg， HA-ID队列的中心脉压（cPP, cSBP-cDBP）为40 mmHg， IDS-TILDA队列为38 mmHg。结论：女性智力障碍患者的中心血压、增压压和增压指数均高于男性，且女性中心血压呈年龄相关性增高。

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来源期刊

Journal of Intellectual Disability Research Multiple-

CiteScore

5.60

自引率

5.60%

发文量

期刊介绍： The Journal of Intellectual Disability Research is devoted exclusively to the scientific study of intellectual disability and publishes papers reporting original observations in this field. The subject matter is broad and includes, but is not restricted to, findings from biological, educational, genetic, medical, psychiatric, psychological and sociological studies, and ethical, philosophical, and legal contributions that increase knowledge on the treatment and prevention of intellectual disability and of associated impairments and disabilities, and/or inform public policy and practice. Expert reviews on themes in which recent research has produced notable advances will be included. Such reviews will normally be by invitation.