Clinical Evidence on the Health Benefits and Safety of Probiotic Lacticaseibacillus rhamnosus: A Systematic Review.

IF 4.4 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Probiotics and Antimicrobial Proteins Pub Date : 2025-07-11 DOI:10.1007/s12602-025-10646-8

Yu Yang, Jing Sui, Wang Liao, Shaokang Wang, Da Pan, Guiju Sun, Peng Gao, Xuesong Xiang, Hui Xia

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Abstract

In recent years, the health benefits of probiotics have received increasing attention. As one of the most common probiotics, the health efficacy and safety of Lacticaseibacillus rhamnosus (L. rhamnosus) have become the research focus. For this reason, the review aimed to comprehensively evaluate the impact of L. rhamnosus on human health and various diseases. PubMed, Embase, Cochrane Library, and Web of Science databases were searched for randomized controlled trials (RCTs) investigating the effect of L. rhamnosus and multiple diseases. A digital search was conducted following systematic review guidelines, and 51 studies met inclusion criteria from a total of 1595 articles. The results of this review indicate that L. rhamnosus provides potential health benefits in various diseases. For example, studies have shown that it may alleviate clinical symptoms of atopic dermatitis in children, modulate gut microbiota to improve symptoms in patients with irritable bowel syndrome (IBS), and potentially reduce the incidence of gestational diabetes mellitus. L. rhamnosus is generally considered safe for healthy individuals, with no serious adverse events commonly reported in the general population. However, occasional adverse effects have been documented in special populations such as critically ill patients, pregnant women, and infants, and caution is advised when used in these groups. Future studies investigating the health benefits of L. rhamnosus still need to design more comprehensive RCTs and expand the sample size to better study the impact of L. rhamnosus on various diseases.

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鼠李糖乳杆菌益生菌健康益处和安全性的临床证据：系统综述。

近年来，益生菌的健康益处越来越受到人们的关注。鼠李糖乳杆菌（lactoaseibacillus rhamnosus， L. rhamnosus）作为最常见的益生菌之一，其保健功效和安全性已成为研究热点。因此，本综述旨在全面评价鼠李糖对人体健康和各种疾病的影响。检索PubMed、Embase、Cochrane Library和Web of Science数据库，寻找随机对照试验（rct），研究鼠李糖对多种疾病的影响。根据系统综述指南进行数字检索，从1595篇文章中筛选出51篇符合纳入标准的研究。本文综述的结果表明，鼠李糖对多种疾病具有潜在的健康益处。例如，研究表明，它可以缓解儿童特应性皮炎的临床症状，调节肠道微生物群以改善肠易激综合征（IBS）患者的症状，并有可能降低妊娠期糖尿病的发病率。鼠李糖通常被认为对健康个体是安全的，一般人群中没有严重的不良事件报道。然而，在危重病人、孕妇和婴儿等特殊人群中偶有不良反应记录，建议在这些人群中谨慎使用。进一步研究鼠李糖的健康益处还需要设计更全面的随机对照试验，扩大样本量，更好地研究鼠李糖对各种疾病的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Probiotics and Antimicrobial Proteins BIOTECHNOLOGY & APPLIED MICROBIOLOGYMICROB-MICROBIOLOGY

CiteScore

11.30

自引率

6.10%

发文量

140

期刊介绍： Probiotics and Antimicrobial Proteins publishes reviews, original articles, letters and short notes and technical/methodological communications aimed at advancing fundamental knowledge and exploration of the applications of probiotics, natural antimicrobial proteins and their derivatives in biomedical, agricultural, veterinary, food, and cosmetic products. The Journal welcomes fundamental research articles and reports on applications of these microorganisms and substances, and encourages structural studies and studies that correlate the structure and functional properties of antimicrobial proteins.