Bifidobacterium's Influential Role in the Battle Against Obesity: Going Beyond Probiotics.

Abstract

Obesity has emerged as a major global health concern, contributing to the development of many chronic illnesses and metabolic conditions. Recent studies underscore the critical role that gut bacteria play in controlling the body's metabolism, with Bifidobacterium species gaining prominence for their diverse effects on the management of obesity. This review considers the knowledge currently accessible about the processes that how Bifidobacterium affects obesity, extending beyond the conventional understanding of probiotics. We explore the probiotic characteristics of Bifidobacterium, which encompass the enhancement of gut homeostasis, the strengthening of intestinal barrier integrity, the mitigation of inflammation as a key factor in obesity pathogenesis, and various other widely recognized beneficial effects. In addition, we discuss the role of Bifidobacterium in metabolic functions and its effects on weight management and associated mechanisms. This review also addresses Bifidobacterium and the multiple elements that lead to obesity, including the interaction with dietary and nutritional elements, the effects of exercise and lifestyle choices, and the consideration of impacts from both the environment and genetics. The evidence and mechanisms presented highlight the beneficial role of Bifidobacterium in managing obesity; however, there remain significant gaps in our comprehensive understanding of its impact on obesity, which we have aimed to address in this review.